MYCN
-
Official Full Name
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -
Overview
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008] -
Synonyms
MYCN;v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog;NMYC;ODED;MODED;N-myc;MYCNOT;bHLHe37;N-myc proto-oncogene protein;pp65/67;oncogene NMYC;neuroblastoma MYC oncogene;class E basic helix-loop-helix protein 37;neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- Insect Cells
- Sf9 Cells
- In Vitro Cell Free System
- Insect cells
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYCN-3128H | Recombinant Human MYCN protein, His-tagged | E.coli | Human | His | 289 - 464 aa | |
| MYCN-10290M | Recombinant Mouse MYCN Protein | Mammalian Cells | Mouse | His |
|
|
| MYCN-11893Z | Recombinant Zebrafish MYCN | Mammalian Cells | Zebrafish | His |
|
|
| MYCN-2766C | Recombinant Chicken MYCN | Mammalian Cells | Chicken | His |
|
|
| MYCN-27993TH | Recombinant Human MYCN protein, GST-tagged | Wheat Germ | Human | GST | 1-464 a.a. |
|
| MYCN-30409TH | Recombinant Human MYCN | Wheat Germ | Human | Non | 100 amino acids |
|
| MYCN-3841R | Recombinant Rat MYCN Protein | Mammalian Cells | Rat | His |
|
|
| MYCN-4036HCL | Recombinant Human MYCN 293 Cell Lysate | HEK293 | Human | Non |
|
|
| MYCN-1468H | Recombinant Human MYCN Protein (1-464 aa), His-tagged | Yeast | Human | His | 1-464 aa |
|
| MYCN-2244H | Recombinant Human MYCN protein, His-tagged | Insect Cells | Human | His | 1-464aa |
|
| MYCN-3500R | Recombinant Rat MYCN Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| MYCN-3500R-B | Recombinant Rat MYCN Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| MYCN-35H | Recombinant Human MYCN Protein (Full length), N-GST-tagged | Sf9 Cells | Human | GST | Full L. Full Length |
|
| MYCN-5832M | Recombinant Mouse MYCN Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| MYCN-5832M-B | Recombinant Mouse MYCN Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| MYCN-7006HF | Recombinant Full Length Human MYCN Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 464 amino acids |
|
| MYCN-8443H | Recombinant Human MYCN protein, His-tagged | Insect cells | Human | His | 1-464aa |
|
Involved Pathway
MYCN involved in several pathways and played different roles in them. We selected most pathways MYCN participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | SIN3A,BCL2A1,LYL1,KDM6A,IL2RB,TSPAN7,HIST2H3C2,TMPRSS2,PML,MMP3 |
Protein Function
MYCN has several biochemical functions, for example, DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYCN itself. We selected most functions MYCN had, and list some proteins which have the same functions with MYCN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SORL1,FAM109A,UTF1,DSCC1,PAEP,EPB41,TMEM119,ELAVL1,ABTB1,Ar |
| protein dimerization activity | NCOA3,MEF2AA,HELT,BETA3,MYCLB,TAL2,ATOH1,POLR2C,MYC,MESPBB |
| DNA binding | OTUD7A,CREBZF,MAP1S,SIX4,MNX2A,ZNF526,TLX2,ZFP426,RBPJ,NFE2L2A |
| transcription factor activity, sequence-specific DNA binding | ZIC3,ZNF286A,ZFP322A,HIVEP2,ZIK1,FOXG1,NFKB1,SOX4,MSRB2,RXRAB |
Interacting Protein
MYCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYCN here. Most of them are supplied by our site. Hope this information will be useful for your research of MYCN.
AURKA;MAX;Aurka;CDKN2A;SIRT1
Resources
Related Services
Related Products
References
- Ramani, P; Nash, R; et al. Aurora kinase A is superior to Ki67 as a prognostic indicator of survival in neuroblastoma. HISTOPATHOLOGY 66:370-379(2015).
- Wang, L; Wu, JZ; et al. Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines. MOLECULAR MEDICINE REPORTS 11:931-939(2015).
