MSRA
-
Official Full Name
MSRA methionine sulfoxide reductase A -
Overview
MSRA carries out the enzymatic reduction of methionine-S-sulfoxide (MetSO) to methionine in thioredoxin-dependent manner. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. The two known splice variants of the mammalian protein are located in mitochondria and the cytosol, respectively. In addition is revealed a MSRA-immunoreactivity into the nuclei of endo-and- myometrium cells oft he human uterus. -
Synonyms
MSRA;methionine sulfoxide reductase A;mitochondrial peptide methionine sulfoxide reductase;peptide Met(O) reductase;peptide met (O) reductase;protein-methionine-S-oxide reductase;peptide methionine sulfoxide reductase;peptide-methionine (S)-S-oxide reductase;cytosolic methionine-S-sulfoxide reductase;PMSR
Recombinant Proteins
- Human
- Bacillus subtilis
- Mouse
- Rat
- Cynomolgus
- E.coli
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&Myc
- GST
Involved Pathway
MSRA involved in several pathways and played different roles in them. We selected most pathways MSRA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MSRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MSRA has several biochemical functions, for example, peptide-methionine (S)-S-oxide reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSRA itself. We selected most functions MSRA had, and list some proteins which have the same functions with MSRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide-methionine (S)-S-oxide reductase activity | TXN2,MSRB1A |
Interacting Protein
MSRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSRA here. Most of them are supplied by our site. Hope this information will be useful for your research of MSRA.
Resources
Related Services
Related Products
References
- Nakajima, T; Matsubara, K; et al. Molecular cloning and characterisation of the methionine sulphoxide reductase A (msrA) gene locus in Campylobacter lari organisms. BRITISH JOURNAL OF BIOMEDICAL SCIENCE 70:135-143(2013).
- Garcia-Bermudez, M; Lopez-Mejias, R; et al. Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 41:350-353(2012).
