MORF4L2
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Official Full Name
mortality factor 4 like 2 -
Overview
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. -
Synonyms
MORF4L2;mortality factor 4 like 2;mortality factor 4-like protein 2;KIAA0026;MORF related gene X;MRGX;MO4L2_HUMAN;MORF related gene X protein;MORF-related gene X protein;MORFL2;Mortality factor 4 like protein 2;MSL3 2 protein;Protein MSL3-2;Transcription factor like protein MRGX;Transcription factor-like protein MRGX;MSL3-2 protein
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK&Myc
- Avi&Fc&His
- GST
Involved Pathway
MORF4L2 involved in several pathways and played different roles in them. We selected most pathways MORF4L2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with MORF4L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | SUDS3,ASH2L,ARID4A,RBBP7,KANSL3,PRDM16,KDM5BB,ACTL6A,GATAD2A,KDM3B |
| HATs acetylate histones | MSL3,ELP4,TADA1,KAT7A,KAT7B,MBIP,PHF15,TAF6L,KAT7,ANO9A |
| Chromatin modifying enzymes | SETD3,ING5B,KAT5,ATF7IP,KDM2AA,ING4,KDM5BB,WDR77,USP22,RUVBL2 |
Protein Function
MORF4L2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MORF4L2 itself. We selected most functions MORF4L2 had, and list some proteins which have the same functions with MORF4L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ABCG8,CPNE3,MAGED1,C9orf9,ACVR2A,FGB,PALLD,IGHM,CD163,GCET2 |
Interacting Protein
MORF4L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MORF4L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MORF4L2.
MRGBP;MRFAP1;CDR2
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References
- Vogt, LM; Meyer, D; et al. Toll-Like Receptor 2 Activation by beta 2 -> 1-Fructans Protects Barrier Function of T84 Human Intestinal Epithelial Cells in a Chain Length-Dependent Manner. JOURNAL OF NUTRITION 144:1002-1008(2014).
- Chantratita, N; Tandhavanant, S; et al. Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide. PLOS ONE 8:-(2013).
