MICB
-
Official Full Name
MHC class I polypeptide-related sequence B -
Overview
MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, ??T cells and CD8+??T cells. Recognition of MICA and MICB by -
Synonyms
MICB;MHC class I polypeptide-related sequence B;PERB11.2;MIC-B;MHC class I mic-B antigen;stress inducible class I homolog;MHC class I chain-related protein B;MHC class I-like molecule PERB11.2-IMX
Recombinant Proteins
- Human
- Rhesus macaque
- HEK293
- Mammalian Cells
- C-hFc
- E.coli
- Human
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- Fc&His
- His
- Fc
- Non
- DDK&Myc
- Avi&Fc&His
- GST
- Avi&His
Involved Pathway
MICB involved in several pathways and played different roles in them. We selected most pathways MICB participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with MICB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | ICAM1,KIR3DL1,MAP2K1,HLA-B,IFNA6,PIK3CA,SYK,Ifna15,Casp3,PAK1 |
Protein Function
MICB has several biochemical functions, for example, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MICB itself. We selected most functions MICB had, and list some proteins which have the same functions with MICB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| natural killer cell lectin-like receptor binding | RAET1L,ULBP2,RAET1G,Mill2,HLA-E,ULBP1,Raet1a,ULBP3,RAET1D,MICA |
Interacting Protein
MICB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MICB here. Most of them are supplied by our site. Hope this information will be useful for your research of MICB.
Resources
Related Services
Related Products
References
- Amin, PJ; Shankar, BS; et al. Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis. LIFE SCIENCES 126:19-27(2015).
- Nowroozpoor-Dailami, K; Mirabi, AM; et al. Aqueous Humor and Serum Concentrations of Soluble MICA and MICB in Glaucoma Patients. IRANIAN JOURNAL OF IMMUNOLOGY 11:275-281(2014).
