METTL1
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Official Full Name
methyltransferase like 1 -
Overview
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. -
Synonyms
METTL1;methyltransferase like 1;C12orf1, methyltransferase like 1;tRNA (guanine-N(7)-)-methyltransferase;TRM8;C12orf1;D1075 like gene product;FLJ95748;Methyltransferase like protein 1;tRNA (guanine N(7) ) methyltransferase;tRNA(m7G46) methyltransferase;YDL201w;D1075-like gene product;methyltransferase-like 1;tRNA(m7G46)-methyltransferase;methyltransferase-like protein 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| METTL1-866H | Recombinant Human METTL1 protein, His-tagged | E.coli | Human | His | Asp32-Gln265 | |
| METTL1-1482Z | Recombinant Zebrafish METTL1 | Mammalian Cells | Zebrafish | His |
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| METTL1-29205TH | Recombinant Human METTL1, His-tagged | E.coli | Human | His | 276 amino acids |
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| METTL1-953H | Recombinant Human METTL1, His-tagged, 33.6kDa (296aa) | E.coli | Human | His |
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| METTL1-9745M | Recombinant Mouse METTL1 Protein | Mammalian Cells | Mouse | His |
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| METTL1-1080HCL | Recombinant Human METTL1 cell lysate | Human | Non |
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| Mettl1-4040M | Recombinant Mouse Mettl1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| METTL1-4411H | Recombinant Human METTL1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| METTL1-5487M | Recombinant Mouse METTL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| METTL1-5487M-B | Recombinant Mouse METTL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| METTL1-6157HF | Recombinant Full Length Human METTL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 276 amino acids |
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| METTL1-946H | Recombinant Human METTL1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
METTL1 involved in several pathways and played different roles in them. We selected most pathways METTL1 participated on our site, such as Gene Expression,tRNA modification in the nucleus and cytosol,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with METTL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA modification in the nucleus and cytosol | TRMT61A,LCMT2,CDKAL1,PUS7,CCDC76,LAGE3,QTRT1,TRMT1,THG1L,TPRKB |
| tRNA processing | ELAC2,TRMT1,TRMT112,RPP38,CCDC76,TRMT61A,OSGEP,RPP30,TSEN54,TSEN2 |
| Gene Expression | NR5A1B,ZNF222,HNRNPL2,SNAPC1B,HNRNPUL1,ZNF791,PTBP1B,ELL,TRMT112,SUPT4H1 |
Protein Function
METTL1 has several biochemical functions, for example, protein binding,tRNA (guanine-N7-)-methyltransferase activity,contributes_to tRNA (guanine-N7-)-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by METTL1 itself. We selected most functions METTL1 had, and list some proteins which have the same functions with METTL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to tRNA (guanine-N7-)-methyltransferase activity | WDR4 |
| tRNA binding | ALKBH8,CARS,AARS2,FARSA,AARS,SSB,EARS2,CTU1,MADD,IGHMBP2 |
| protein binding | UBE2D2A,PIM3,PRL,CRYBA2,TNKS,UBASH3B,STX8,ZNF622,SEC22A,FANCM |
Interacting Protein
METTL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METTL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of METTL1.
WDR4;ssrna_ug
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References
- Gray, SG; et al. Epigenetic-based immune intervention for rheumatic diseases. EPIGENOMICS 6:253-271(2014).
- Ju, JY; Wang, Y; et al. Human fetal globin gene expression is regulated by LYAR. NUCLEIC ACIDS RESEARCH 42:9740-9752(2014).
