MEF2C
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Official Full Name
myocyte enhancer factor 2C -
Overview
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. -
Synonyms
MEF2C;myocyte enhancer factor 2C;myocyte-specific enhancer factor 2C;MADS box transcription enhancer factor 2, polypeptide C;C5DELq14.3;DEL5q14.3
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- Avi&Fc&His
- DDK&Myc
- GST
- Flag
Involved Pathway
MEF2C involved in several pathways and played different roles in them. We selected most pathways MEF2C participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEF2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF3,FGF14,PRKCB,NFKB1,KCNA3,CACNG8,MAPK12,FGF12,CACNA1SA,FGF13A |
| Oxytocin signaling pathway | CAMK2B,OXT,CACNB3,ROCK1,NPR2,PLCB2,CAMK1,CACNG7,RHOA,CAMK1G |
| Transcriptional misregulation in cancer | PAX5,MAF,CD86,H3F3B,GOLPH3,PPARG,PFTK1,CLSTN2,BMP2K,MEIS1 |
| cGMP-PKG signaling pathway | IRS1,CREB3L2,PIK3R3,ATF4,SLC25A5,GNA11,RHOA,ITPR1,PDE2A,CALM3 |
Protein Function
MEF2C has several biochemical functions, for example, AT DNA binding,DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEF2C itself. We selected most functions MEF2C had, and list some proteins which have the same functions with MEF2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GATA3,MEOX2,NFATC2,FOXJ1,PITX1,NR4A2,FOXC2,TCF21,ZFP292,POU2F3 |
| DNA binding | CEBPB,VDRA,NKX2.2B,HES7,BHLHE22,RPP21,NR0B2,ZNF764,TFDP1,POU3F3A |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | HNF1B,TLE4,T,JUN,CEBPA,LEF1,NR5A2,GATA4,MYOD1,NKX2-5 |
| RNA polymerase II regulatory region sequence-specific DNA binding | FERD3L,ATF3,FOXK1,ZBTB4,ATF4B1,MNT,DMBX1,TFAP2D,SP5,ZNF561 |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | HEY1,TFAP2B,HEYL,MAX,NKX3,HEY2,PAX7,SMAD3 |
| miRNA binding | AGO2,TRIM71,PNPT1,TARBP2,DICER1,AGO1,LIN28A,AGO4,SOX2,RBM4 |
| transcription factor activity, sequence-specific DNA binding | PBX2,TP73,ZHX1,PBX3B,ASCL1B,PRDM2,ZNF302,TBX19,NKX2-8,SCAND1 |
| chromatin binding | POLA1,LHX2,KLF14,ING2,C19orf40,NOC3L,RAD51,SMC1AL,SOX15,NOC2L |
| AT DNA binding | HMGA2,HMGA1,CRIP1,POU3F4 |
Interacting Protein
MEF2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEF2C here. Most of them are supplied by our site. Hope this information will be useful for your research of MEF2C.
MYLK2;HDAC4;Hdac5;EP300;TFCP2;Mylk2;YWHAZ;SPTBN1;MAPK7;MAPK14;COPS5;EPAS1;PLA2G12A;HDAC9;HDAC7;HDAC5
Resources
Research Area
Cardiac Stem Cell MarkersTranscription Factors in the Akt Pathway
Cancer Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Neural Stem Cell Transcription Factors
Pluripotent Stem Cell Transcription Factors
Related Services
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References
- Yu, ZS; Kong, JJ; et al. Islet-1 May Function as an Assistant Factor for Histone Acetylation and Regulation of Cardiac Development-Related Transcription Factor Mef2c Expression. PLOS ONE 8:-(2013).
- Madonna, R; Wu, DL; et al. Myocardin-A enhances expression of promyogenic genes without depressing telomerase activity in adipose tissue-derived mesenchymal stem cells. INTERNATIONAL JOURNAL OF CARDIOLOGY 167:2912-2921(2013).
