MECP2
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Official Full Name
methyl CpG binding protein 2 (Rett syndrome) -
Overview
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009] -
Synonyms
MECP2;methyl CpG binding protein 2 (Rett syndrome);RS;RTS;RTT;PPMX;MRX16;MRX79;MRXSL;AUTSX3;MRXS13;methyl-CpG-binding protein 2;meCp-2 protein
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
MECP2 involved in several pathways and played different roles in them. We selected most pathways MECP2 participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MECP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | CC2D1A,TPH2,ASCL1,ECE1,CREM,POU3F2,EN1,TPPP,LMX1B,CHRFAM7A |
Protein Function
MECP2 has several biochemical functions, for example, DNA binding,chromatin binding,double-stranded methylated DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MECP2 itself. We selected most functions MECP2 had, and list some proteins which have the same functions with MECP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | BHLHE40,FOS,SIX1B,EFCAB11,ASCL2,ZFP82,HOXD4A,MYCH,MSC,ZFP367 |
| protein binding | BSG,KRTAP3-1,ZFAND6,SLC25A6,WAS,HRAS,DAB1,PA2G4,FRS3,HOXC4 |
| poly(A) RNA binding | RPL36,EIF4A1,SNRPG,PAN3,RRS1,PRPF8,XRCC6,RPL36A,TRMT1,DHX30 |
| transcription corepressor activity | CIR1,ZHX3,TRIM28,BCOR,SUFU,JUNB,SIAH2,DDX54,ELK3,ZBTB32 |
| protein N-terminus binding | NTSR1,TAF11,TGFB1,TSC1,NBN,STX5,KCNB1,FEZ1,EIF5A,PEX5 |
| histone deacetylase binding | RFXANK,ANKRD1,NRIP1,PRDM1,BCOR,ZNF703,FOXP3,PKN1,ANKRA2,DDX20 |
| siRNA binding | TLR9,TLR7,DICER1,TARBP2,AGO2 |
| DNA binding | POLR3B,NKX2-1,ZFP473,FOXG1B,EEPD1,FOXA,CERS5,HOXA10B,ZBTB20,SP6 |
| mRNA binding | SSB,RBM25,NUDT21,RBM5,HSP26,IGF2BP1,KHSRP,TDRD7,NXF2,CROP |
Interacting Protein
MECP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MECP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MECP2.
Hipk2;SMARCA2;64mer_ds_dna_probe;Atrx;HIPK2;SOX18;AIM2;H2AFY;PYHIN1
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References
- Papini, AM; Nuti, F; et al. Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction. JOURNAL OF IMMUNOLOGY RESEARCH :-(2014).
- Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
