ME2
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Official Full Name
malic enzyme 2, NAD(+)-dependent, mitochondrial -
Overview
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. -
Synonyms
ME2;malic enzyme 2, NAD(+)-dependent, mitochondrial;NAD-dependent malic enzyme, mitochondrial;NAD-ME;malate dehydrogenase;pyruvic-malic carboxylase;ODS1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- His&T7
- Flag
- Myc&DDK
- GST
Involved Pathway
ME2 involved in several pathways and played different roles in them. We selected most pathways ME2 participated on our site, such as Pyruvate metabolism,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ME2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyruvate metabolism | ALDH3A2A,ackA,ALDH2.2,LDHAL6B,GRHPR,PDK3B,PKLR,PDK3,ACYP1,PC |
| Carbon metabolism | HK2,GOT2A,SDHDA,GOT2B,ALDOCA,SHMT2,ADH5,SDS,ackA,HADHAB |
Protein Function
ME2 has several biochemical functions, for example, NAD binding,electron carrier activity,malate dehydrogenase (decarboxylating) (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ME2 itself. We selected most functions ME2 had, and list some proteins which have the same functions with ME2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| malate dehydrogenase (decarboxylating) (NAD+) activity | ME1,ME3 |
| malic enzyme activity | ME1,MDH1,ME3 |
| NAD binding | GPD1B,HSD17B10,IDH3A,IDH1,LDHB,GPD1L,MDH1,AOX4,ME3,GPD1A |
| metal ion binding | XPNPEP2,UNC13C,EXTL3,ZBTB9,KLK4,SALL1,ZFY2,GMIP,ZC4H2,PPP1CA |
| oxaloacetate decarboxylase activity | ME3,FAHD1,ME1 |
| electron carrier activity | FDX1L,CYP1A2,NQO2,XDH,GLRX5,ACADM,ACAD9,GSR,ALDH4A1,COX7A1 |
Interacting Protein
ME2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ME2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ME2.
ATIC;RAB11A;WNK1;USP15;ssrna_ag;ICT1;SIRT4
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References
- Diao, YF; Oqani, RK; et al. Changes in Histone H3 Lysine 36 Methylation in Porcine Oocytes and Preimplantation Embryos. PLOS ONE 9:-(2014).
- Hua, RH; Huo, H; et al. Generation and Efficacy Evaluation of Recombinant Classical Swine Fever Virus E2 Glycoprotein Expressed in Stable Transgenic Mammalian Cell Line. PLOS ONE 9:-(2014).
