MBTPS1
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Official Full Name
membrane-bound transcription factor peptidase, site 1 -
Overview
The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. -
Synonyms
MBTPS1;membrane-bound transcription factor peptidase, site 1;membrane bound transcription factor protease, site 1;membrane-bound transcription factor site-1 protease;KIAA0091;PCSK8;S1P;SKI 1;MGC138711;MGC138712;membrane bound transcription factor peptidase, site 1;S1P endopeptidase;Site 1 protease;SKI1;Subtilisin/kexin isozyme 1;site-1 protease;endopeptidase S1P;subtilisin/kexin isozyme-1;subtilisin/kexin-isozyme 1;membrane-bound transcription factor protease, site 1;SKI-1
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cells
- His
- GST
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
MBTPS1 involved in several pathways and played different roles in them. We selected most pathways MBTPS1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBTPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | SEC23B,CAPN1A,SEL1L2,ATXN3,UBE2E3,RRBP1,PKZ,RAD23AB,SEC61G,UBE2E2 |
Protein Function
MBTPS1 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MBTPS1 itself. We selected most functions MBTPS1 had, and list some proteins which have the same functions with MBTPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | ST14A,CTRL,PCSK4,PROZ,TMPRSS11D,APEH,TMPRSS4B,PCSK6,PROC,CORIN |
Interacting Protein
MBTPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBTPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBTPS1.
Dlg4;SMAP;TNFSF11;CDK2AP2;q81n31_bacan;ZBED8;TNFRSF14
Resources
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References
- Cinaroglu, A; Gao, C; et al. Activating Transcription Factor 6 Plays Protective and Pathological Roles in Steatosis Due to Endoplasmic Reticulum Stress in Zebrafish. HEPATOLOGY 54:495-508(2011).
- Popkin, DL; Teijaro, JR; et al. Hypomorphic Mutation in the Site-1 Protease Mbtps1 Endows Resistance to Persistent Viral Infection in a Cell-Specific Manner. CELL HOST & MICROBE 9:212-222(2011).
