MAPKAPK5
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Official Full Name
mitogen-activated protein kinase-activated protein kinase 5 -
Overview
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. -
Synonyms
MAPKAPK5;mitogen-activated protein kinase-activated protein kinase 5;MAP kinase-activated protein kinase 5;PRAK;MAPKAPK-5;MAPKAP kinase 5;MAPK-activated protein kinase 5;p38-regulated/activated protein kinase;MK5;MK-5;MAPKAP-K5
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- S.frugiperda
- Sf9 Insect Cell
- Insect Cell
- Mammalian Cell
- Insect Cells
- E.coli
- HEK293
- Insect (sf21)
- His&GST
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
MAPKAPK5 involved in several pathways and played different roles in them. We selected most pathways MAPKAPK5 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPKAPK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | GRB2B,MEF2CA,PPP3CCA,RELA,ACVR1C,GADD45AA,RPS6KA3,FGF10A,HSPA1L,MINK1 |
Protein Function
MAPKAPK5 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,calcium-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPKAPK5 itself. We selected most functions MAPKAPK5 had, and list some proteins which have the same functions with MAPKAPK5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MYO5B,SF3A2,EMX2,AGER,IPO11,NOX1,GTF3C4,FAM154A,PSTPIP1,USP13 |
| MAP kinase kinase activity | MAPK14,MAP2K2B,MAPK10,LRRK2,MAP3K14,MAP2K3,PAK3,ALPK2,MAP2K7,MAP2K1 |
| calcium-dependent protein serine/threonine kinase activity | MKNK2B,CAMK1GB,MAPKAPK2,MAPKAPK2B,MKNK1,MKNK2,CAMK1GA,CAMK4,MKNK2A,MAPKAPK2A |
| p53 binding | CDK5,CDKN2AIP,DAXX,CHD8,HSPD1,EHMT1,ZNF346,ZMAT3,RFFL,RNF20 |
| calmodulin-dependent protein kinase activity | MYLK3,CAMK1,CAMK2D1,CAMK1GB,CAMKK1,MKNK2B,MAPKAPK2B,DAPK2A,CAMK2D,CAMK2B1 |
| ATP binding | ETNK2,PRKCBB,CAMK4,NLRP4,ROCK1,NAIP6,ATP13A4,KIF17,PGK2,NLRP2 |
| signal transducer activity | PLCH2,VMN1R46,NPFFR1L2,TAS2R110,OLFCG3,PLCD1B,GPR177,GNGT2B,CXCR4A,TAS2R200.1 |
| mitogen-activated protein kinase binding | MAPKAPK2A,PLCB4,NBR1,GTF2I,MAPK7,ATF7,MAPKAPK2B,ACE,TPR,ARRB2 |
| calmodulin binding | MYO3A,RIT2,INVS,KCNH5,EPB41,TTN,TJP1,SCN5A,CAMK2B,CAMK2D1 |
Interacting Protein
MAPKAPK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPKAPK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPKAPK5.
MAPK6;saicar;TP53;HSPB1;PKM;SRPK2;SRPK1;MAPK1;MAPK9;EIF4EBP1;RPL13;TAB1;MAPK14
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References
- Lee, WJ; Ou, HC; et al. Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. JOURNAL OF VASCULAR SURGERY 52:1290-1300(2010).
- Jamesdaniel, S; Ding, DL; et al. Analysis of Cochlear Protein Profiles of Wistar, Sprague-Dawley, and Fischer 344 Rats with Normal Hearing Function. JOURNAL OF PROTEOME RESEARCH 8:3520-3528(2009).
