MAPK13
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Official Full Name
mitogen-activated protein kinase 13 -
Overview
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. -
Synonyms
MAPK13;mitogen-activated protein kinase 13;PRKM13;p38delta;SAPK4;MAPK 13;MAP kinase 13;MAP kinase p38 delta;stress-activated protein kinase 4;mitogen-activated protein kinase p38 delta;MGC99536
Recombinant Proteins
- Human
- Mouse
- E.coli
- Insect Cells
- Human
- Sf9 Insect Cell
- Insect Cell
- HEK293T
- HEK293
- His
- GST
- Non
- Myc&DDK
- His&SUMO
Involved Pathway
MAPK13 involved in several pathways and played different roles in them. We selected most pathways MAPK13 participated on our site, such as MAPK signaling pathway,Rap signaling pathway,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leishmaniasis | HLA-DRB1,ITGB2L,PRKCB,HLA-DMB,HLA-DQA1,IL12B,ITGAM,IFNGR2,CR1,TGFB2 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1C2,PLCG2,ATP6V1B1,IKBKG,ATP6AP1,ATP6V1G1,PAK1,MAPK8,TJP1,CCL5 |
| Shigellosis | RHOG,ROCK2,U2AF1L4,CD44,ELMO1,ITGB1,RAC1,WASL,IKBKB,IL-8 |
| Influenza A | IL6,NXF3,IFNA6,TLR3,RSAD2,HLA-DQB1,IL12B,IFNA16,IFNGR1,TRIM25 |
| Epstein-Barr virus infection | TBK1,Fcer2a,NUP214,POLR2A,CSNK2A2,SHFM1,ITGAL,GTF2B,YWHAG,MAPK9 |
| Signaling pathways regulating pluripotency of stem cells | PCGF1,PCGF3,TBX3,ID3,ZIC3,KRAS,FGFR4,INHBC,MEIS1,WNT8A |
| MAPK signaling pathway | MAP3K5,CDC25B,CACNB2A,PAK2,MAP3K14,NRAS,CACNG6A,AKT1,MAPK8A,FGF4 |
| T cell receptor signaling pathway | TNF,CD3E,CDC42,SLA1,ICOS,PLCG1,DBNLB,CD28,RELA,IL4 |
| Sphingolipid signaling pathway | FCER1G,TRP53,PPP2R2D,GNAQ,PPP2R5D,SPTLC3,DEGS1,S1PR5,NFKB1,MAPK10 |
Protein Function
MAPK13 has several biochemical functions, for example, ATP binding,MAP kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK13 itself. We selected most functions MAPK13 had, and list some proteins which have the same functions with MAPK13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAP3K7IP3,RUVBL2,CLPB,HP1BP3,EPB41,DACT1,TGFBR1,NR5A1,HIST4H4,MTIF3 |
| MAP kinase activity | MAPK12B,MAPK6,MAPK14B,NLK,MAPK7,NLK1,MAPK15,MAPK14,MAPK4,MAPK8B |
| protein serine/threonine kinase activity | DCLK3,MAP3K8,DAPK1,STK33,SGK2A,DCLK1,DCLK2,AKT2,STK25,SYK |
| ATP binding | PKN3,SBK3,ORC4,GARS,CSNK1A1L,PKM,BLM,KIF5C,PIK3C2A,PIP5K1A |
Interacting Protein
MAPK13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK13.
PRKD1;FPR1;saicar;PKM;ATF2;MAPKAPK3;Pkd1;MAP3K4;GPX4;SMAD4;ANKLE2;AKIP1;pi3p
MAPK13 Related Signal Pathway
Resources
Research Area
Apoptosis Intracellular KinasesDiabetic Peripheral Neuropathy
p38 MAP Kinases
Intracellular Signaling Molecules in Angiogenesis
Reperfusion Injury Therapeutic Targets
Rheumatoid arthritis Therapeutic Targets
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
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References
