Lypla1
-
Official Full Name
lysophospholipase I -
Overview
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. -
Synonyms
LYPLA1;lysophospholipase I;acyl-protein thioesterase 1;Acyl protein thioesterase 1;APT 1;APT1;LPL1;LYPLA 1;LYSOPLA;LPL-I;lysoPLA I;lysophospholipase 1;acyl-protein thioesterase-1;lysophospholipid-specific lysophospholipase;APT-1;hAPT1
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Mouse
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- His&Fc&Avi
- GST
Involved Pathway
Lypla1 involved in several pathways and played different roles in them. We selected most pathways Lypla1 participated on our site, such as Choline metabolism in cancer,Glycerophospholipid metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lypla1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| eNOS activation | CYGB1,ZDHHC21,CYGB2,CYGB,DDAH1,DDAH2 |
| Choline metabolism in cancer | PRKCG,RHEB,MAPK10,SLC22A2,SLC5A7,MAPK3,GPCPD1,PLA2G4A,DGKD,PLA2G4B |
| Metabolism | CPT2,AK8,CYGB2,CYP2V1,NDOR1,COX15,ACY3,DECR1,CYP3A7-CYP3AP1,G0S2 |
| Metabolism of nitric oxide | CYGB2,NOSTRIN,CYGB1,GCHFR,ZDHHC21,CYGB,SPRB,DDAH1,NOSIP,DDAH2 |
| eNOS activation and regulation | DDAH1,CYGB,CYGB2,DDAH2,NOSIP,SPRB,ZDHHC21,GCHFR,NOSTRIN,CYGB1 |
| Glycerophospholipid metabolism | CRLS1,GPD1C,PLA2G4AA,PPAP2C,PPAP2A,PLA2G12A,DGKE,PLA2G2A,AGPAT5,CHAT |
Protein Function
Lypla1 has several biochemical functions, for example, lipase activity,lysophospholipase activity,palmitoyl-(protein) hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lypla1 itself. We selected most functions Lypla1 had, and list some proteins which have the same functions with Lypla1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipase activity | CES1C,NOTUM1A,LIPA,CEL.1,LIPN,LIPK,Aadacl3,GOLT1BB,ABHD2A,DAGLB |
| lysophospholipase activity | PNPLA8,PLA2G4A,PNPLA7,PNPLA6,Cel,PLA2G15,PLA2G4AA,ENPP2,PLA2G4B,PLB1 |
| palmitoyl-(protein) hydrolase activity | LYPLA2,LYPLAL1,PPT2,PPT1 |
Interacting Protein
Lypla1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lypla1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Lypla1.
VHL;IKBKE;NS;VCAM1
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References
- Aerts, I; Martin, JJ; et al. The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade. CLINICAL NEUROLOGY AND NEUROSURGERY 113:224-229(2011).
- Dennis, J; White, MA; et al. Phosphodiesterase-I alpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization. MOLECULAR AND CELLULAR NEUROSCIENCE 37:412-424(2008).
