LYN
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Official Full Name
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog -
Overview
Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivale -
Synonyms
LYN;v-yes-1 Yamaguchi sarcoma viral related oncogene homolog;tyrosine-protein kinase Lyn;JTK8;lck/Yes-related novel protein tyrosine kinase;p53Lyn;p56Lyn;FLJ26625
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- Insect (sf21)
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- Insect cell
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
- His&Myc
- His&GST
Involved Pathway
LYN involved in several pathways and played different roles in them. We selected most pathways LYN participated on our site, such as Chemokine signaling pathway,NF-kappa B signaling pathway,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | HIST1H4G,CASP8,CDC42,CREB5,TRP53,DDX3X,PIK3CB,HLA-B,CCNE2,CCND3 |
| Chemokine signaling pathway | CCL3,AKT1,GRK1,CXCL14,IKBKG,PTK2,NFKB1,CXCL3,GM13304,DOCK2 |
| Epstein-Barr virus infection | PIK3CD,MAPK10,HSPA2,PRKACA,HLA-DRA,POLR3H,H2-Q10,SHFM1,PIK3CG,PSMD8 |
| Platelet activation | FGB,PLCB1,MAPK1,NOS3,GP9,GUCY1B3,PIK3CA,MAPK13,STIM1,GP5 |
| B Cell Receptor Signaling Pathway | VAV3,IFITM1,BCL2L11,cgr2b,NFATC1,NFKBIB,CD72,GRB2,MAP2K2,DOK3 |
| Long-term depression | PLA2G4D,ITPR3,GRIA3,PRKG1,GNAI1,PPP2CA,PLCB2,PLCB4,ARAF,MAP2K2 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1G2,RELA,ATP6V0A1,ATP6V1B1,PLCG1,ATP6V1C2,ATP6V1E1,CCL5,ATP6V1C1,ATP6V1G1 |
| Fc epsilon RI signaling pathway | PLA2G4D,FCER1G,AKT2,MAP2K1,TNF,PIK3CA,PLA2G4B,GM-CSF,PIK3CD,RAC1 |
| NF-kappa B signaling pathway | PIDD1,Ccl21c,CFLAR,NFKBIA,TAB2,BCL2L1,TLR4,BTK,LTA,BCL2 |
Protein Function
LYN has several biochemical functions, for example, ATP binding,SH3 domain binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LYN itself. We selected most functions LYN had, and list some proteins which have the same functions with LYN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | CTGFB,VTN,CALR,L1CAM,ADAM10,CTGFA,TGFBI,THBS4,FBN1,DMP1 |
| gamma-tubulin binding | NDN,RAD51D,BLOC1S2A,BRCA2,BLOC1S2,CEP57,TUBGCP5,RAD51L3,TUBGCP3,SPATC1 |
| SH3 domain binding | WIPF3,CASP9,USP8,QKI,CD3E,SH3BP1,ARHGAP17,FAM125A,DENND1A,SH3BP2 |
| ATP binding | CIT,PKZ,EPHA4A,DYRK1AA,TAF1,ATAD1B,FLT4,PKM2,EEF2K,PSMC4 |
| ion channel binding | PRKCSH,FGF12,PRNP,FKBP1B,EPN1,KCNIP1,CHERP,DLG1,KCNB1,ABCC9 |
| receptor signaling protein tyrosine kinase activity | TYRO3,EGFR,SYK,KITA,EGFRA,ERBB4,ERBB4A,KIT,KITB,ERBB2 |
| protein binding | NAA38,TTI1,ASS1,FBXO9,CYB5R1,EFCAB4A,PIPOX,VAMP3,NOS3,THOC5 |
| phosphoprotein binding | IGF2R,THRAP3,PIH1D1,MS4A2,PITX2,FKBP4,TRPV1,SERPINB1A,DPYS,TBK1 |
| enzyme binding | UGT1A6B,MAT2B,CNTNAP2,YWHAE,Il6ra,UGT1A2,RAD9A,GBP1,CFTR,ESR1 |
Interacting Protein
LYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYN here. Most of them are supplied by our site. Hope this information will be useful for your research of LYN.
EGFR;polg_hcvh;polg_hcvco;KHDRBS1;polg_hcvj4;PTK2;tip_shv2c
Resources
Research Area
Intracellular Kinases in the Akt PathwaySrc Kinases
Negative Regulators of the Jak/STAT Pathway
B Cell Receptor-Associated Proteins
Related Services
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References
- Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
- Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).
