LPAR4
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Official Full Name
lysophosphatidic acid receptor 4 -
Overview
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. -
Synonyms
LPAR4;lysophosphatidic acid receptor 4;G protein coupled receptor 23 , GPR23;LPA4;P2RY9;P2Y5 LIKE;P2Y9;LPA-4;LPA receptor 4;P2Y purinoceptor 9;P2Y5-like receptor;purinergic receptor 9;G protein-coupled receptor 23;G-protein coupled receptor 2
Recombinant Proteins
- Chicken
- Mouse
- Human
- Mus musculus
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LPAR4-5330C | Recombinant Chicken LPAR4 | Mammalian Cells | Chicken | His |
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| LPAR4-9192M | Recombinant Mouse LPAR4 Protein | Mammalian Cells | Mouse | His |
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| LPAR4-4724H | Recombinant Human LPAR4 Protein | Wheat Germ | Human | Non |
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| LPAR4-5135M | Recombinant Mouse LPAR4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LPAR4-5135M-B | Recombinant Mouse LPAR4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| LPAR4-5971HF | Recombinant Full Length Human LPAR4 Protein | In Vitro Cell Free System | Human | Full L. 424 amino acids |
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| RFL17293MF | Recombinant Full Length Mouse Lysophosphatidic Acid Receptor 4(Lpar4) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-370) |
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| RFL26756HF | Recombinant Full Length Human Lysophosphatidic Acid Receptor 4(Lpar4) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-370) |
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Involved Pathway
LPAR4 involved in several pathways and played different roles in them. We selected most pathways LPAR4 participated on our site, such as Rap signaling pathway,Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | PTK2B,PIP5K1B,AGPAT4,INSR,GRM1,FCER1G,MAPK1,KIT,PPAP2B,PLD2 |
| Pathways in cancer | RASSF1,GLI2,MSH3,WNT3A,NTRK1,KRAS,KITLG,GNG4,LAMB3,WNT5B |
| Rap signaling pathway | MRAS,MET,GNAQ,FGF2,FGF17,VAV2,PRKD3,Adcy4,Fgf15,ACTB |
| PIK-Akt signaling pathway | CCNE2,TLR4,PIK3CG,THBS4,ATF4,PGF,FASLG,IL3RA,LPAR5,MAP2K1 |
| Neuroactive ligand-receptor interaction | TACR1A,GABRA2,TAAR14D,GRIK5,P2RY1,MAS1,UTS2R,PTH1RA,GRIA1A,GRIN2C |
Protein Function
LPAR4 has several biochemical functions, for example, G-protein coupled receptor activity,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR4 itself. We selected most functions LPAR4 had, and list some proteins which have the same functions with LPAR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | FFAR1,FZD6,ACKR3B,TAAR8B,OLFR5,OR10W1,VMN1R48,CHRM5B,GPR15,NPY8BR |
| lipid binding | SH3GL1,PFN3,CRABP2B,APOA1A,ACBD6,EPN3,SH3GLB1,PLUNC,PCYT1A,HSP12 |
Interacting Protein
LPAR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR4.
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References
- Hu, JC; Oda, SK; et al. Lysophosphatidic Acid Receptor 5 Inhibits B Cell Antigen Receptor Signaling and Antibody Response. JOURNAL OF IMMUNOLOGY 193:85-95(2014).
- Ni, Y; Sinnett-Smith, J; et al. PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors. PLOS ONE 8:-(2013).
