LIMS1

  • Official Full Name

    LIM and senescent cell antigen-like domains 1

  • Overview

    The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

  • Synonyms

    LIMS1;LIM and senescent cell antigen-like domains 1;PINCH;PINCH1;PINCH-1;LIM and senescent cell antigen-like-containing domain protein 1;renal carcinoma antigen NY-REN-48;particularly interesting new Cys-His protein 1

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • Insect Cell
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&T7
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
LIMS1-1873H Recombinant Human LIMS1 protein, GST-tagged E.coli Human GST 1-325 aa
LIMS1-1161C Recombinant Chicken LIMS1 Mammalian Cell Chicken His
LIMS1-29952TH Recombinant Human LIMS1 Wheat Germ Human Non 325 amino acids
LIMS1-2996Z Recombinant Zebrafish LIMS1 Mammalian Cell Zebrafish His
LIMS1-9110M Recombinant Mouse LIMS1 Protein Mammalian Cell Mouse His
LIMS1-4736HCL Recombinant Human LIMS1 293 Cell Lysate HEK293 Human Non
LIMS1-1507H Recombinant Human LIMS1 protein, His & T7-tagged E.coli Human His&T7 Ala68~Cys303
LIMS1-2655M Recombinant Mouse LIMS1 Protein (2-325 aa) E.coli Mouse Non 2-325 aa
LIMS1-2784M Recombinant Mouse LIMS1 Protein (2-325 aa), His-tagged Insect Cell Mouse His 2-325 aa
LIMS1-284HF Recombinant Full Length Human LIMS1 Protein In Vitro Cell Free System Human Full L. 325 amino acids
LIMS1-4448H Recombinant Human LIMS1 Protein (Ala68-Cys303), N-His tagged E.coli Human His Ala68-Cys303
LIMS1-5087M Recombinant Mouse LIMS1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
LIMS1-5087M-B Recombinant Mouse LIMS1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    LIMS1 involved in several pathways and played different roles in them. We selected most pathways LIMS1 participated on our site, such as Cell junction organization,Cell-Cell communication,Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell-extracellular matrix interactions TESK1,ITGB1B.1,PARVB,FBLIM1,FERMT2,RSU1
    Cell-Cell communication DCC,CDH11,PARVB,JUP,CLDN16,INADL,KIRREL3L,COL17A1A,DSCAMA,CDH13
    Cell junction organization CDH24,COL17A1A,CADM2B,FERMT2,F11R.2,PARVB,JUP,CDH18A,CLDN4,CLDN23
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components TESK1,RSU1,PARVB

    Protein Function

    LIMS1 has several biochemical functions, for example, protein binding,protein kinase binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMS1 itself. We selected most functions LIMS1 had, and list some proteins which have the same functions with LIMS1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PXMP2,MARK2,SARM1,KCNH2,CENPO,CTDSP2,OGN,ADRB3,CALU,TBC1D5
    zinc ion binding PDZRN3B,TRIM55A,LONRF3,IRGF4,ZFAND5B,RNF2,RERE,PHF17,MMP14B,FBXO40.1
    protein kinase binding ATF2,ADIPOR1,TBL2,PEBP1,SMAD3,TPRKB,PIFO,PTPN23,PPME1,PDPK1

    Interacting Protein

    LIMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMS1.

    ILK;RSU1;NCK2;Ilk;Hoxa1

    Resources

    Research Area

    EMT Induction
    Focal Adhesion Adaptor and Scaffold Proteins

    References

    • Li, SH; Bordoy, R; et al. PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. JOURNAL OF CELL SCIENCE 118:2913-2921(2005).

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