LDHA
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Official Full Name
lactate dehydrogenase A -
Overview
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008] -
Synonyms
LDHA;lactate dehydrogenase A;LDH1;LDHM;GSD11;PIG19;HEL-S-133P;L-lactate dehydrogenase A chain;LDH-A;LDH-M;LDH muscle subunit;lactate dehydrogenase M;proliferation-inducing gene 19;renal carcinoma antigen NY-REN-59;cell proliferation-inducing gene 19 protein;epididymis secretory sperm binding protein Li 133P
Recombinant Proteins
- Mouse
- Human
- Rat
- Rhesus macaque
- Chicken
- Pig
- Zebrafish
- Lactobacillus plantarum
- Staphylococcus Aureus
- Insect Cell
- Human Erythrocyte
- Human Heart
- HEK293
- Mammalian cells
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- Chicken
- His
- Non
- Myc&DDK
- Flag
- GST
- His&GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
LDHA involved in several pathways and played different roles in them. We selected most pathways LDHA participated on our site, such as Glycolysis / Gluconeogenesis,Cysteine and methionine metabolism,Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Propanoate metabolism | DLDH,ECHDC1,SUCLA2,HADHAA,LDHAL6B,LDHC,HADHAB,LDHBA,HADHA,SUCLG1 |
| Metabolic pathways | AOX4,CHDH,IDH3B,CYP2B19,LPCAT4,ALOX5A,SMPD1,NADKD1,MRI1,ALAS2 |
| HIF- signaling pathway | VEGFA,ANGPT2,NOS2,NOX1,TFRC,MAP2K2,ENO2,ANGPT1,ENO1,PLCG1 |
| Glycolysis / Gluconeogenesis | PKM2,PKMA,ACSS2L,PFKM,MINPP1,ADH6,TPI1,ALDOAA,ADH4,HK2 |
| Pyruvate metabolism | PDK3B,PDPR,PDK2B,ME3,MDH1AA,ME2,ALDH9A1B,ME1,ACACB,BRP44 |
| Central carbon metabolism in cancer | NTRK1,HK3,PGAM1,IDH1,PDHB,SLC2A1,PIK3CD,FGFR2,PDGFRB,SLC1A5 |
| Cysteine and methionine metabolism | CBSA,LDHBA,GOT2B,LDHC,GCLC,BCAT1,MTR,TAT,DNMT4,MAT2A |
Protein Function
LDHA has several biochemical functions, for example, L-lactate dehydrogenase activity,NAD binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDHA itself. We selected most functions LDHA had, and list some proteins which have the same functions with LDHA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SERPINB1A,ITGB3,PRNP,DES,ATXN10,IK,STAC3,ENTPD2,EID3,RALYL |
| NAD binding | AHCY,AOX1,CYB5R3,NNT,SORD,GPD1B,CTBP1,HSD3B4,HSD17B10,GAPDH |
| L-lactate dehydrogenase activity | LDHBB,LDHBA,LDHB,LDHAL6B,LDHAL6A,LDHC |
| protein binding | ADAMTSL4,RAET1D,FAM60A,EPOR,PDK1,OPRD1,DPYSL5,VAMP5,SEPT12,POLB |
| kinase binding | STRADA,DLG4,DUSP12,DLG3,GFAP,PFKM,PPP2R5A,SGOL1,HAP1,EMP2 |
Interacting Protein
LDHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDHA here. Most of them are supplied by our site. Hope this information will be useful for your research of LDHA.
HSPA8;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;pyruvate;nadh;YWHAZ;TFAP2A;LDHB;TERF1;hpaX;dppC3;ydaJ;XRN1;metE
Resources
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References
- Yip, SSM; Zhou, MX; et al. Complete Knockout of the Lactate Dehydrogenase A Gene is Lethal in Pyruvate Dehydrogenase Kinase 1, 2, 3 Down-Regulated CHO Cells. MOLECULAR BIOTECHNOLOGY 56:833-838(2014).
- Grimm, M; Cetindis, M; et al. Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
