LAIR1
-
Official Full Name
leukocyte-associated immunoglobulin-like receptor 1 -
Overview
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. -
Synonyms
LAIR1;leukocyte-associated immunoglobulin-like receptor 1;leukocyte associated Ig like receptor 1;CD305;5133400O11Rik;D7Bwg0421e;hLAIR1;LAIR 1;LAIR-1;LAIR1 protein;LAIR1_HUMAN;Leukocyte associated immunoglobulin like receptor 1;OTTHUMP00000068183;OTTHUMP00000068184;OTTHUMP00000068185;OTTHUMP00000068186;OTTHUMP00000068187;leukocyte-associated Ig-like receptor 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- HEK293
- E.coli
- Mammalian Cells
- Insect Cells
- Human Cells
- Avi
- His
- Non
- Fc
- hIgG4
- Flag
- Twin Strep
- DDK
- Myc
- mFc
- mIgG2a
Involved Pathway
LAIR1 involved in several pathways and played different roles in them. We selected most pathways LAIR1 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAIR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | FBXO17,EDA,CYBB,ATG7,SIGLEC9,MGC174155,ASB7,ASB10,GHRB,MB21D1 |
| Adaptive Immune System | CLTC,SH2D1B,RNF144B,KLHL20,TRAT1,ASB13,MALT1,GRAP2B,DYNC1H1,DCTN2 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | GM11711,CLEC2H,CD300A,LAIR2,SIGLEC8,SIGLEC6,LILRA1,CD300LF,CD160,KLRG1 |
Protein Function
LAIR1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAIR1 itself. We selected most functions LAIR1 had, and list some proteins which have the same functions with LAIR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HEYL,PAK1,ARHGAP33,SMPDL3A,SERPING1,ORAI3,MEPE,ITM2B,PTPLAD1,ERCC6L |
Interacting Protein
LAIR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAIR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAIR1.
PTPN6;CSK
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesLAIR Family
T Cell Migration
CD Antigen (T Cell Migration/Adhesion)
Monocyte Markers
Other Proteins Involved in Regulating B Cell Activation
Dendritic Cell ITIM/ITAM Immunoreceptors
Related Services
Related Products
References
