KLK2
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Official Full Name
kallikrein-related peptidase 2 -
Overview
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012] -
Synonyms
KLK2;kallikrein-related peptidase 2;hK2;hGK-1;KLK2A2;kallikrein-2;tissue kallikrein-2;glandular kallikrein 2;glandular kallikrein-1;kallikrein 2, prostatic
Recombinant Proteins
- Human
- Mammalian cells
- HEK293
- Wheat Germ
- E.coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
KLK2 involved in several pathways and played different roles in them. We selected most pathways KLK2 participated on our site, such as Renin-angiotensin system,Endocrine and other factor-regulated calcium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocrine and other factor-regulated calcium reabsorption | PTH1R,PLCB1,PLCB4,PRKACA,GNAS,KLK1B24,KLK1B9,PRKCB,ATP1A2,ATP1B3 |
| Renin-angiotensin system | PREP,THOP1,PRCP,CMA1,AGTR1B,MRGPRD,ACE2,CTSA,NLN,LNPEP |
Protein Function
KLK2 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK2 itself. We selected most functions KLK2 had, and list some proteins which have the same functions with KLK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PRSS38,MCPT9,TYSND1,TMPRSS4,PLAU,PRSS21,HABP2,PRSS44,FURINB,KLK5 |
Interacting Protein
KLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK2.
Resources
Research Area
Serine Proteases and RegulatorsFibrinolysis System
Kinin System
Prostate Cancer Biomarkers
Related Services
Related Products
References
