ITGB3BP
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Official Full Name
integrin beta 3 binding protein (beta3-endonexin) -
Overview
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. -
Synonyms
ITGB3BP;integrin beta 3 binding protein (beta3-endonexin);centromere protein R;CENPR;HSU37139;NRIF3;TAP20;Beta3 endonexin;CENP R;Integrin beta 3 binding protein;NRIF 3;Nuclear receptor interacting factor 3;TAP 20;beta 3 endonexin;beta-3-endonexin;OTTHUMP00000015392;OTTHUMP00000015409;OTTHUMP00000015410;integrin beta-3-binding protein;nuclear receptor-interacting factor 3;CENP-R
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
ITGB3BP involved in several pathways and played different roles in them. We selected most pathways ITGB3BP participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cell death signalling via NRAGE, NRIF and NADE, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB3BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Deposition of new CENPA-containing nucleosomes at the centromere | RBBP7,MIS18BP1,CENPL,MIS18A,HJURP,CENPH,NPM1,CENPI,CENPA,CENPP |
| Mitotic Anaphase | SGOL1,NUF2,ZWINT,SPC25,NDEL1B,CENPH,ZWILCH,MIS12,MLF1IP,WAPAL |
| Cell cycle | CDC14A,CUL1B,MND1,FZR1,CDH1-A,HJURP,MCM6,CSNK2A1,VRK1,MDM2 |
| Cell death signalling via NRAGE, NRIF and NADE | AATF,ARHGAP4,ARHGEF18A,MCF2L,ARHGEF9,TIAM2,PLEKHG2,TRIO,FGD4A,ARHGEF16 |
| Mitotic Metaphase and Anaphase | CDCA8,MLF1IP,ZWINT,KNTC1,SGOL1,CDCA5,WAPAL,ANKLE2,NSL1,CENPL |
| M Phase | NCAPH,NEK7,MASTL,APITD1,ARPP19A,NDEL1,ENSAA,CENPC1,NDEL1B,NEK6 |
| Chromosome Maintenance | MLF1IP,CENPQ,TINF2,ACD,HJURP,RBBP4,MIS18A,RUVBL2,CENPA,DNA2 |
| Cell Cycle, Mitotic | GOLGA2,SMC4,SPC24,LMNB1,CDCA8,CEP152,LEMD3,CENPO,CENPK,KNTC1 |
Protein Function
ITGB3BP has several biochemical functions, for example, protein C-terminus binding,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB3BP itself. We selected most functions ITGB3BP had, and list some proteins which have the same functions with ITGB3BP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RAB3IP,TGM2,MST1R,VRK1,MAGOHB,CTCFL,KBTBD7,ATP6V0D1,MYD88,NFASC |
| protein C-terminus binding | MID1IP1,SNX17,KCNIP3,SP1,ERCC1,VGLL2,PHB2,ITPR1,NCL,MIF4GD |
| signal transducer activity | VMN1R46,GNG2,FKBP1A,OPN1SW1,RGRB,CBLB,ADRB3B,GNAL,TAAR10A,EDNRAB |
Interacting Protein
ITGB3BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB3BP here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB3BP.
ARFIP2;COL4A3BP;KIFC3;HIP1;SVIL;KDM1A;OFD1;WFS1;RECQL5;ALDH2;PDHA1;ACTG1
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