ITGA2B
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Official Full Name
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -
Overview
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] -
Synonyms
ITGA2B;integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41);GT;GTA;CD41;GP2B;HPA3;CD41B;GPIIb;BDPLT2;BDPLT16;integrin alpha-IIb;GPalpha IIb;platelet-specific antigen BAK;platelet membrane glycoprotein IIb;platelet fibrinogen receptor, alpha subunit
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Macaca mulatta
- E.coli
- Mammalian Cells
- Human Plasma
- HEK293
- Yeast
- Wheat Germ
- GST
- His
- T7
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
- SUMO
Involved Pathway
ITGA2B involved in several pathways and played different roles in them. We selected most pathways ITGA2B participated on our site, such as Rap signaling pathway,PIK-Akt signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | CALM3,FGF9,MLLT4,PDGFB,FGF21,VASP,RAP1GAP,PFN3,RAPGEF1,MAPK12 |
| Focal adhesion | FN1A,CAPN2A,RAC2,VAV3,FYNB,XIAP,MYLPF,ACTB,PDGFB,CAV2 |
| Pathways in cancer | MSH2,CYCS,WNT7A,TGFBR1,STAT3,TRAF4,KIT,WNT7B,HSP90AB1,MITF |
| Small cell lung cancer | RB1,LAMB4,TP53,RXRG,AKT1,BIRC7,LAMA4,LAMC2,NFKBIA,BIRC2 |
| PIK-Akt signaling pathway | PKN2,MAP2K1,GNB1,PPP2R5B,KLK1B4,FGF20,TLR4,FLT1,PPP2R5C,GYS1 |
| Hematopoietic cell lineage | CD1E,CD1D2,HLA-DRB1,IL4,ITGA4,Il4ra,IL5RA,HLA-DRB4,CD22,Flt3l |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSP,CTNNA2,ACTB,SGCB,ACTN1,ITGA6,CACNG7,EMD,CACNG8,ITGA2 |
| ECM-receptor interaction | THBS2,COL5A1,ITGA6,GP1BA,LAMC2,COMP,COL1A2,LAMB2,SV2A,TNW |
| Platelet activation | SNAP23,ACTB,VWF,LCP2,PLCB3,PIK3R1,TBXA2R,SRC,PIK3CA,MAPK3 |
Protein Function
ITGA2B has several biochemical functions, for example, extracellular matrix binding,fibrinogen binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2B itself. We selected most functions ITGA2B had, and list some proteins which have the same functions with ITGA2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | MAT1A,FKBP8,TENC1,HGS,ARSH,CAR15,ZFP609,ZNF471,AARS2,TMPPE |
| extracellular matrix binding | SPOCK2,TGFBI,SPARC,CD248,ITGAV,VTN,SID4,ITGB3,FBLN2,SPP1 |
| fibrinogen binding | MFAP2,THBS1,FBLN1 |
| identical protein binding | GRB7,UAP1,EPOR,FBLN1,STAC3,ABCD1,BAIAP2,COL1A2,S100A2,BIN1 |
| protein binding | GKAP1,SQSTM1,DRD2,TMSB4Y,SETBP1,UBE2Z,RIC8,YRDC,CXXC1,DDX39A |
Interacting Protein
ITGA2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2B.
ITGB3;g3gu78_crigr
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References
- Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).
- Nishikawa, S; Arai, S; et al. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. BLOOD 124:3587-3596(2014).
