ITGA2
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Official Full Name
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -
Overview
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. -
Synonyms
ITGA2;integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor);CD49B;integrin alpha-2;CD49b;integrin alpha 2;collagen receptor;VLA-2 subunit alpha;platelet antigen Br;platelet glycoprotein Ia;platelet glycoprotein GPIa;CD49 antigen-like fam
Recombinant Proteins
- Rhesus macaque
- Cattle
- Human
- Mouse
- Monkey
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- Mammalian cells
- Wheat Germ
- His
- His&S
- His&GST
- Non
- His&Fc&Avi
- His&SUMO
- GST
- His&Strep
Involved Pathway
ITGA2 involved in several pathways and played different roles in them. We selected most pathways ITGA2 participated on our site, such as Phagosome,PIK-Akt signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | LMNA,ACE,RYR2,ITGB3,ITGA3,PRKAB1,PRKAA1,ITGB7,ITGA8,ITGA10 |
| Dilated cardiomyopathy | TNNI3,CACNA2D3,ITGB6,CACNG2,TNNC1,PRKACB,PLN,TPM1,CACNB3,CACNB1 |
| Platelet activation | PRKACB,ROCK2,MAPK1,FYN,MYLK3,PLCB1,RAP1A,PTGS1,MAPK12,PIK3CB |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSG2,SLC8A1,ACTN2,CTNNA3,ITGB4,ITGA7,LAMA2,ITGA9,DSP,ITGB8 |
| ECM-receptor interaction | COL27A1A,SPP1,ITGB3B,ITGB7,COMP,ITGB3,ITGA1,COL11A2,ITGB1B.2,COL6A4 |
| Phagosome | TUBA3D,CALRL2,ITGA5,TUBA1L2,ITGB5,ATP6V0A1B,RAB7B,NOS1,H2-Q10,ATP6V1E1B |
| Focal adhesion | PPP1R12B,PAK7,MYLPFB,ITGA5,RHOAB,CCND1,CCND3,PIK3CD,ACTN2B,LAMB1 |
| Small cell lung cancer | PIK3CG,IKBKB,NFKB1,LAMA4,ITGA3,PIK3R1,AKT1,PTK2,FHIT,RARB |
| Hematopoietic cell lineage | GM13305,CD1D,GYPA,CD8B1,ITGA4,CD24,CD33, B2M,ITGA3,FLT3LG |
Protein Function
ITGA2 has several biochemical functions, for example, collagen binding,collagen binding involved in cell-matrix adhesion,collagen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2 itself. We selected most functions ITGA2 had, and list some proteins which have the same functions with ITGA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | CD44,NID2,DDR2,DCN,LRRC15,ITGA3,Pdgfa&Pdgfb,MRC2,SMAD7,PDGFA |
| metal ion binding | PPP2CA,GTPBP8,GM3258,PTGS2,GLRX5,ZDHHC5A,CYP2B19,ZNF576.2,RPS27A,DAGLB |
| protein binding | CENPI,TMEM115,DAB1,MMP2,PEX11A,UBE2D4,CHMP2A,SOX30,KDM6B,FUBP3 |
| collagen binding involved in cell-matrix adhesion | ITGA1,Itga10&Itgb1,ITGA10,ITGB1 |
| virus receptor activity | SLC20A2,EFNB2,HAVCR1,PVRL2,GPR172B,PVR,CXCR4,CLEC4M,SELPLG,SLC10A1 |
Interacting Protein
ITGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2.
SHARPIN;Rab21;ITGB1;FABP3;COL1A2;PDIA3;Rab21
Resources
Research Area
Natural Killer Cells (NK Cells) MarkersIntegrins
Focal Adhesion Proteins in VSMC
Natural Killer T (NKT) Cells
Integrins in Focal Adhesions
Basolateral Molecules
Related Services
Related Products
References
- Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
- Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
