INHA
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Official Full Name
inhibin, alpha -
Overview
Activin A is a homodimer of 14kDa beta-A. Activin A, a cytokine member of the transforming growth factor-beta superfamily, is expressed locally by the mesenchymal component of the hemopoietic microenvironment. Its expression is regulated on the mRNA level by different cytokines, and the biological activity of the protein is tightly controlled by several inhibitory molecules. Inhibins and activins are members of the transforming growth factor beta superfamily and are known to modulate the growth and differentiation of several cell types. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. The standard product used in this kit is recombinant Activin A, which is composed of two single chains of 116 amino acids with the molecular mass of 26KDa. -
Synonyms
Activin A;INHA;inhibin, alpha
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Cattle
- Pig
- Mycobacterium tuberculosis
- Mycobacterium Tuberculosis
- Bovine
- CHO
- E.coli
- Mammalian Cells
- Human
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Yeast
- Non
- His
- T7
- GST
- His&GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
INHA involved in several pathways and played different roles in them. We selected most pathways INHA participated on our site, such as Glycoprotein hormones,Metabolism of proteins,Ovarian Infertility Genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with INHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycoprotein hormones | CGB7,CGB5,INHBAA |
| Peptide hormone biosynthesis | CGB5,CGB7,INHBAA,PCSK1 |
| Ovarian Infertility Genes | NRIP1,ZP2,DAZL,GJA4,DMC1,ZP3,NR5A1,SYNE2,MSH5 |
| Peptide hormone metabolism | CMA1,SLC30A8,GZMH,INHBAA,SLC38A8,EXOC8,GRP,SLC30A6,GPR120,CGB7 |
| Metabolism of proteins | CXXC1,B3GALTL,IGFBP6B,HYOU1,ST6GAL2B,CPB2,MUC12,PFDN2,MGAT4A,ADAMTS3 |
Protein Function
INHA has several biochemical functions, for example, cytokine activity,growth factor activity,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INHA itself. We selected most functions INHA had, and list some proteins which have the same functions with INHA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | IL29,HSPA1A,GBA,GFRA1,CAPRIN2,AMN,WNT7AA,SERPINE1,GSTK1,SLC9A3R1 |
| cytokine activity | Ccl27a,IL1RN,GDF10,IFNE,TXLNA,TGFB1,IFNA7,GRN,IL32,IL17B |
| hormone activity | CRHR2,CSH2,PTH1A,CHGB,EDN2,STC1L,PTH,SST2,AGT,CGA |
| protein heterodimerization activity | HIST1H4E,NAE1,BCL2A1,BAXA,SYT10,TAF4B,MCL1,BCL11A,NKX2-5,HIST1H4A |
| contributes_to protein binding | MLH1,TAF10,PAK1,MSH2,TGFBR3,MSH6,MEF2A,CPSF3L,INTS10,POLR2A |
| inhibin binding | INHBA,ACVR1B,IGSF1,ACVR2A |
| protein binding | TCEB3B,NRBF2,ADD1,CARHSP1,CMKLR1,GRIN2C,TXNRD3,RPP25L,CYBRD1,IQCE |
| transforming growth factor beta receptor binding | TGFBR3,GDF1,MSTNB,MSTNA,BMP6,INHBAA,TGFBRAP1,LEFTY1,SMAD2,NODAL |
| growth factor activity | LEP,BMP7A,NTF3,Fgf15,FGF2,VEGFC,FGF18,NENF,THBS4B,GDF5 |
Interacting Protein
INHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INHA here. Most of them are supplied by our site. Hope this information will be useful for your research of INHA.
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References
- Marino, FE; Risbridger, G; et al. The inhibin/activin signalling pathway in human gonadal and adrenal cancers. MOLECULAR HUMAN REPRODUCTION 20:1223-1237(2014).
- Masieri, S; Trabattoni, D; et al. A role for Waldeyer's ring in immunological response to allergens. CURRENT MEDICAL RESEARCH AND OPINION 30:203-205(2014).
