ING2
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Official Full Name
inhibitor of growth family, member 2 -
Overview
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. -
Synonyms
ING2;inhibitor of growth family, member 2;ING1L, inhibitor of growth family, member 1 like;inhibitor of growth protein 2;p33ING2;p32;ING1Lp;inhibitor of growth 1-like protein;ING1L
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ING2 involved in several pathways and played different roles in them. We selected most pathways ING2 participated on our site, such as Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Senescence and Autophagy | SLC39A1,IL24,COL10A1,IFI16,LC3,MAP1LC3B,RSL1D1,FKBP8,CREG1,ATG7 |
Protein Function
ING2 has several biochemical functions, for example, DNA binding,chromatin binding,methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING2 itself. We selected most functions ING2 had, and list some proteins which have the same functions with ING2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KLC4,NTRK1,ING5,NDFIP1,CLEC4G,FOXC2,CHPF,EMP3,C21orf119,BAI2 |
| DNA binding | ZNF621,PRDM2,SIX3B,LASS2,ZFP382,SSH1,SOX32,ZNF434,BRIP1,SIX1B |
| zinc ion binding | PPARDB,MARCH7,BTR02,MID2,TRIM41,USP3,ISL1,QPCT,L3MBTL4,ADH1C |
| phosphatidylinositol binding | GRB7,SGK3,SNX33,WDR35,SNX31,NCF1,SNX15,TUB,PXK,MTM1 |
| protein complex binding | PLK2,RPTOR,UGT1A6A,ULK1,LCA5,RBM10,YWHAB,LEPRE1,RBX1,PAFAH1B1 |
| methylated histone binding | CAPNS2,PHF19,ING3,CBX5,RAG2,TDRD3,CHD1,ATRX,PHF8,CCDC101 |
| chromatin binding | RELB,NCOA5,DHX30,RFX4,DNAJC2,HMGB2,ATOH1A,CHD7,REST,PHF13 |
Interacting Protein
ING2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING2.
PCNA;SMURF1;h3;TP53;UBC;SUMO1;H3F3A;EP300;SIN3A;SMURF1;h3_peptide_2-18;ostp_human_gene;tmm71_human_gene;SAP30;HDAC1
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References
- Su, ZL; Boersma, MD; et al. ChIP-less analysis of chromatin states. EPIGENETICS & CHROMATIN 7:-(2014).
- Garske, AL; Oliver, SS; et al. Combinatorial profiling of chromatin binding modules reveals multisite discrimination. NATURE CHEMICAL BIOLOGY 6:283-290(2010).
- Jager, D; Stockert, E; et al. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: Characterization of tissue-specific ING1 transcripts and a homologue gene. CANCER RESEARCH 59:6197-6204(1999).
