Il12rb2
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Official Full Name
interleukin 12 receptor, beta 2 -
Overview
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense. -
Synonyms
IL12RB2;interleukin 12 receptor, beta 2;interleukin-12 receptor subunit beta-2;I12R2_HUMAN;IL-12 receptor subunit beta-2;IL-12R subunit beta-2;IL-12R-beta-2;IL-12RB2;IL12 receptor beta 2;IL12R beta2;Interleukin 12 receptor beta 2;Interleukin 12 receptor beta 2 chain;RP11 102M16.1;IL-12 receptor beta 2;interleukin-12 receptor beta-2 chain;RP11-102M16.1
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- Cynomolgus
- HEK293
- Mammalian Cells
- E.coli
- Wheat Germ
- Yeast
- Human Cells
- Insect Cells
- His
- Fc
- Fc&His
- GST&His
- Non
- Avi&Fc&His
- mFc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Il12rb2-4006M | Active Recombinant Mouse Il12rb2 protein, His-tagged | HEK293 | Mouse | His | Met1-Asn637 | |
| IL12RB2-73H | Recombinant Human IL12RB2 protein, Fc-tagged | HEK293 | Human | Fc | ||
| IL12RB2-9483H |
Active Recombinant Human IL12RB2 Protein, Fc/His-tagged
|
Mammalian Cells | Human | Fc&His | 24-622 a.a. |
|
| IL12RB2-1464H | Recombinant Human IL12RB2 protein, His-tagged | E.coli | Human | His | Trp145~Ala275 |
|
| IL12RB2-1465H | Recombinant Human IL12RB2 protein, His & GST-tagged | E.coli | Human | GST&His | Tyr559~Gln647 |
|
| Il12rb2-1466M | Recombinant Mouse Il12rb2 protein, His-tagged | E.coli | Mouse | His | Met285~Gln441 |
|
| Il12rb2-1467M | Recombinant Mouse Il12rb2 protein, His-tagged | E.coli | Mouse | His | Thr455~Arg606 |
|
| IL12RB2-29640TH | Recombinant Human IL12RB2 | Wheat Germ | Human | Non | 110 amino acids |
|
| IL12RB2-3884H | Recombinant Human IL12RB2 protein, His-tagged | Yeast | Human | His | 24-622aa |
|
| IL12RB2-5006C | Recombinant Chicken IL12RB2 | Mammalian Cells | Chicken | His |
|
|
| IL12RB2-6304Z | Recombinant Zebrafish IL12RB2 | Mammalian Cells | Zebrafish | His |
|
|
| IL12RB2-2142MCL | Recombinant Mouse IL12RB2 cell lysate | Human Cells | Mouse | Non |
|
|
| IL12RB2-214H | Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
|
| IL12RB2-214H-B | Recombinant Human IL12RB2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| IL12RB2-3230H | Recombinant Human IL12RB2 Protein, His-tagged | HEK293 | Human | His |
|
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| IL12RB2-3233H | Active Recombinant Human IL12RB2 protein, His-tagged | HEK293 | Human | His | Lys 24 - Asn 622 |
|
| IL12RB2-34C | Recombinant Cynomolgus IL12RB2 protein, mFc-tagged | HEK293 | Cynomolgus | mFc | Lys24-Asn623 |
|
| IL12RB2-3885H | Recombinant Human IL12RB2 protein, His-tagged | Insect Cells | Human | His | Met1-Asn622 |
|
| Il12rb2-5695M | Recombinant Mouse Il12rb2 Protein (Met1-Asn637), C-Fc tagged | Mammalian Cells | Mouse | Fc | Met1-Asn637 |
|
Involved Pathway
Il12rb2 involved in several pathways and played different roles in them. We selected most pathways Il12rb2 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Il12rb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | IFNW1,IL6ST,PIK3R3A,Ifna15,IFNA7,IL23,GHRA,IL11RA,CISHB,IFNA4 |
| Inflammatory bowel disease (IBD) | HLA-DRB1,IL18,SMAD3,IL12RB1,IL22,HLA-DPB1,IL21R,STAT3,IFNGR1,RORA |
| Cytokine-cytokine receptor interaction | GM13306,IFNPHI1,VEGFB,IL11,CRFB4,IL3,Fasl,IL20RA,EDA2R,TNFSF8 |
Protein Function
Il12rb2 has several biochemical functions, for example, cytokine receptor activity,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il12rb2 itself. We selected most functions Il12rb2 had, and list some proteins which have the same functions with Il12rb2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CHEK2,RHOD,TNIP2,SMAD1,GSTP2,ATG13,MAP3K5,GATA6,MAPK6,CCNB1 |
| cytokine receptor activity | F3B,IL1RL1,IL31RA,CRFB4,CRFB16,LIFRB,IL17RB,IL2RGA,CSF3R,IL28RA |
Interacting Protein
Il12rb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il12rb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il12rb2.
STAT4;SOCS3
Il12rb2 Related Signal Pathway
Resources
Research Area
Negative Regulators of the Jak/STAT PathwayReceptors in the Jak/STAT Pathway
T Cell Cytokine Signaling
Th1 Cells
IL-12 Family Receptors
Related Services
Related Products
References
- Holle, JU; Gross, WL; et al. Genetic risk factors for vasculitis. INTERNIST 55:128-+(2014).
- Cho, S; Kim, J; et al. Immunopathogenic characterization of cutaneous inflammation in Behcet's disease. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 28:51-57(2014).
