IFIH1
-
Official Full Name
interferon induced with helicase C domain 1 -
Overview
Interferon-induced helicase C domain-containing protein 1, also know as MDA5 (Melanoma Differentiation-Associated protein 5), is an enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. -
Synonyms
IFIH1;interferon induced with helicase C domain 1;Hlcd;MDA5;MDA-5;IDDM19;MGC133047;interferon-induced helicase C domain-containing protein 1;helicard;OTTHUMP00000162935;CADM-140 autoantigen;helicase with 2 CARD domains;RNA helicase-DEAD box protein 116;murabutide down-regulated protein;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;melanoma differentiation associated protein-5;melanoma differentiation-associated protein 5;interferon-induced with helicase C domain protein 1;clinically amyopathic dermatomyositis autoantigen 140 kDa
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Confidential
- Insect Cells
- Baculovirus
- His
- Non
- Flag
- Avi&Fc&His
- DDK&Myc
- His&SUMO
- His&V5
Involved Pathway
IFIH1 involved in several pathways and played different roles in them. We selected most pathways IFIH1 participated on our site, such as RIG-I-like receptor signaling pathway,Hepatitis B,Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFIH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | IKBKE,CLOCKB,TAF6L,ARNTL1A,IL6,TNFRSF14,RNASEL,TAF6,TLR2-2,IRF9 |
| Influenza A | HLA-DRB3,EIF2AK3,VDAC1,IL12B,NFKBIB,RSAD2,MAP2K4,NFKB1,TLR3,MAPK9 |
| RIG-I-like receptor signaling pathway | IFNA3,Ifna15,IFNA8,TBKBP1,NFKBIB,MAPK12A,ATG12,IFNK,IKBKE,MAPK8 |
| Measles | IFNA13,TRP53,IFNAR1,CD46,BBC3,OAS2,IFNGR2,IFNA12,IFNA7,CCND1 |
| Hepatitis B | IKBKG,IFNA10,ATF4,OSTN,CREB3L3,SRC,TIRAP,DDX58,Ifna11,BIRC5 |
Protein Function
IFIH1 has several biochemical functions, for example, ATP binding,DNA binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFIH1 itself. We selected most functions IFIH1 had, and list some proteins which have the same functions with IFIH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribonucleoprotein complex binding | WDR12,RNASEL,PITX2,TIMM50,PRMT7,CKAP5,PPIH,ITCH,SRP54,PQBP1 |
| ATP binding | Abcb1b,ASS1,MYH15,SKIV2L,KIF17,JAK2,ABCB11,NLRP2,HSP104,EK1 |
| helicase activity | NAV2,DHX32A,UPF1,DDX51,RAD54L,TDRD9,PEO1,ZRANB3,MOV10B.1,DDX58 |
| zinc ion binding | CPA1,MMP1A,RC3H2,JHDM1D,BPTF,RFPL4,GCH2,LIMK1A,WBP4,KDM5BA |
| DNA binding | FOXD5,TP63,NR2F6,ZC3H3,DNASE2,KIF4,TDP2B,ZNF326,SCXB,FOXM1 |
| single-stranded RNA binding | ENDOV,LUZP4,ANXA1,CNBP,HMGB1,IFIT5,CBX8,AGO1,JMJD6,CBX6 |
| double-stranded RNA binding | SLC3A2,ILF2,ZFP346,APTX,DICER1,STAU2,TARBP2,OASL2,AGO3,LSM14A |
| protein binding | IGSF1,ENOX2,KCNE4,NQO2,SEC23B,ATOX1,SNAP29,GAK,ERCC5,PHLPP1 |
Interacting Protein
IFIH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFIH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFIH1.
MAVS;US11;DDX3X;P/V/C;P/V;P/V;P/V;P/V/C;P/V/C;P/V
Resources
Related Services
Related Products
References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Enevold, C; Kjaer, L; et al. Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. RHEUMATOLOGY INTERNATIONAL 34:1401-1408(2014).
