IDH1

  • Official Full Name

    isocitrate dehydrogenase 1 (NADP+), soluble
  • Overview

    Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate.
  • Synonyms

    Cytosolic NADP isocitrate dehydrogenase;Cytosolic NADP-isocitrate dehydrogenase;ICDH;IDCD;IDH;IDH1;IDHC_HUMAN;IDP;IDPC;Isocitrate dehydrogenase [NADP] cytoplasmic;Isocitrate dehydrogenase 1 (NADP+) soluble;NADP dependent isocitrate dehydrogenase cytosolic;NADP dependent isocitrate dehydrogenase peroxisomal;NADP(+)-specific ICDH;Oxalosuccinate decarboxylase;PICD;Isocitrate dehydrogenase

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Rat
  • Mouse
  • E.coli
  • Insect Cells
  • HEK293
  • Mammalian Cells
  • Human
  • His
  • Flag
  • DDK
  • Myc
  • Non
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
IDH1-14047H Recombinant Human IDH1, His-tagged E.coli Human His C-term-74a.a.
IDH1-030H Recombinant Human IDH1 (R132H mutation) Protein, His-tagged E.coli Human His 2-414
IDH1-043H Active Recombinant Human IDH1 Protein, His-tagged Insect Cells Human His
IDH1-044H Active Recombinant Human IDH1 Protein, DDK-tagged Insect Cells Human Flag
IDH1-1044H Active Recombinant Human IDH1 Protein, His-tagged E.coli Human His Met1-Leu414
IDH1-042H Recombinant Human IDH1 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
IDH1-108H Recombinant Human IDH1(G97D) Protein, His-tagged E.coli Human His 1-414
IDH1-109H Recombinant Human IDH1(R100A) Protein, His-tagged E.coli Human His 1-414
IDH1-110H Recombinant Human IDH1(R100Q) Protein, His-tagged E.coli Human His 1-414
IDH1-111H Recombinant Human IDH1(R132C) Protein, His-tagged E.coli Human His 1-414
IDH1-112H Recombinant Human IDH1(R132H) Protein, His-tagged E.coli Human His 1-414
IDH1-114H Recombinant Human IDH1(Y139D) Protein, His-tagged E.coli Human His 1-414
IDH1-11544Z Recombinant Zebrafish IDH1 Mammalian Cells Zebrafish His
IDH1-1284H Recombinant Human Isocitrate Dehydrogenase 1 (NADP+), Soluble, His-tagged Human Human His
IDH1-2191R Recombinant Rhesus monkey IDH1 Protein, His-tagged Mammalian Cells Rhesus macaque His
IDH1-246H Recombinant Human IDH1 Mammalian Cells Human His
IDH1-2527H Active Recombinant Human IDH1 protein, His-tagged, SEC-HPLC verified E.coli Human His Met 1 - Leu 414
IDH1-2985R Recombinant Rat IDH1 Protein Mammalian Cells Rat His
IDH1-5849H Recombinant Human IDH1 protein, DDK-tagged Insect Cells Human Flag
IDH1-7984M Recombinant Mouse IDH1 Protein Mammalian Cells Mouse His
IDH1-5307HCL Recombinant Human IDH1 293 Cell Lysate HEK293 Human Non
IDH1-0133H Recombinant Human IDH1 Protein (S2-L414), Tag Free E.coli Human Non S2-L414
IDH1-0134H Recombinant Human IDH1 Protein (S2-L414), His tagged E.coli Human His S2-L414
IDH1-022H Recombinant Human IDH1 Protein, His-tagged E.coli Human His
IDH1-023H Recombinant Human IDH1 Protein, His-tagged E.coli Human His 2-414
IDH1-029H Recombinant Human IDH1 Protein, His-tagged E.coli Human His
IDH1-1116HFL Recombinant Full Length Human IDH1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IDH1-1134H Recombinant Human IDH1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IDH1-1134H-B Recombinant Human IDH1 Protein Pre-coupled Magnetic Beads HEK293 Human
Idh1-1212M Recombinant Mouse Idh1 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
IDH1-13H Active Recombinant Human IDH1 Protein (1-414aa), N-His tagged E.coli Human His 1-414 aa
Idh1-1583M Recombinant Mouse Idh1 protein, His & GST-tagged E.coli Mouse GST&His Ile99~Thr325
Idh1-1584R Recombinant Rat Idh1 protein, His-tagged E.coli Rat His Pro78~Ile330
IDH1-2012R Recombinant Rhesus Macaque IDH1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IDH1-2012R-B Recombinant Rhesus Macaque IDH1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IDH1-2640R Recombinant Rat IDH1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IDH1-2640R-B Recombinant Rat IDH1 Protein Pre-coupled Magnetic Beads HEK293 Rat
IDH1-3029H Recombinant Human IDH1 Protein(1-414aa), His-tagged E.coli Human His 1-414aa
IDH1-3401H Recombinant Human IDH1 Protein (Met1-Leu414), His tagged E.coli Human His Met1-Leu414
IDH1-4409M Recombinant Mouse IDH1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IDH1-4409M-B Recombinant Mouse IDH1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IDH1-565M Recombinant Mouse IDH1 Protein (7-407 aa), His-tagged E.coli Mouse His 7-407 aa
IDH1-5679HFL Recombinant Full Length Human IDH1 protein, Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    IDH1 involved in several pathways and played different roles in them. We selected most pathways IDH1 participated on our site, such as Citrate cycle (TCA cycle),Glutathione metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biosynthesis of amino acids THA1,PYCR1A,PRPS1L1,GPT,ASL,IDH3A,RPE,TPI1A,TAT,CBSA
    Central carbon metabolism in cancer SLC16A3,TRP53,SLC2A2,SIRT3,PDGFRA,PFKL,RAF1,C12orf5,HK2,MAP2K1
    -Oxocarboxylic acid metabolism GOT2,ACO2,BCAT2,GPT2L,IDH3G,AADAT,GOT1,IDH2,GOT2B,GPT2
    Metabolic pathways ADH1B,NSDHL,PAH,NT5E,PNLIP,GK2,RRM2,TPH2,PKMB,DHRS3B
    Carbon metabolism PDHA1,ACAT2,ECHS1,SHMT1,ackA,CPS1,DLAT,SHMT2,H6PD,ENO2
    Peroxisome ABCD2,IDH2,PEX10,SCP2,PEX3,MPV17L2,NUDT7,MPV17,GNPAT,ACAA1A
    Citrate cycle (TCA cycle) PDHB,PDHA2,ACLY,IDH3G,PC,PCK2,SUCLA2,PDHA1A,PCK1,IDH3B
    Glutathione metabolism OPLAH,GPX4B,GPX1,GPX8,MGST2,GGT1,GGT7,GSTT2B,GPX4A,GSTM1

    Protein Function

    IDH1 has several biochemical functions, for example, NAD binding,NADP binding,isocitrate dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH1 itself. We selected most functions IDH1 had, and list some proteins which have the same functions with IDH1. You can find most of the proteins on our site.

    Function Related Protein
    NAD binding DLD,HIBADHA,IDH3B,CTBP2A,GAPDH,AOX4,GPD1L,AOX3,GRHPR,LDHA
    protein homodimerization activity P2RX7,VIL1,CUL3,CISD2,UGT1A9,MFF,CREB3,KIAA0947,ZHX3,HPS4
    magnesium ion binding ALPP,STK36,PTENB,PTENA,BPNT1,PPM1A,PPM1NB,NUAK2,NT5C1BA,ENO1B
    receptor binding HLA-E,GRIN2A,LIF,F2R,LPL,RND1,PVRL3B,HNF4A,TENM2,IDE
    NADP binding NOX5,DHFRL1,SPR,FMO5,POR,ASPDH,NNT,PGD,NOS2,ME1
    isocitrate dehydrogenase (NADP+) activity IDH2

    Interacting Protein

    IDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH1.

    gltX;mtfA;CEP57L1;ZHX1;15-deoxy-delta(12,14;ere_dna

    Resources

    References

    • Bunse, L; Schumacher, T; et al. Proximity ligation assay evaluates IDH1(R132H) presentation in gliomas. JOURNAL OF CLINICAL INVESTIGATION 125:593-606(2015).
    • Kawasoe, T; Takeshima, H; et al. Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme. JOURNAL OF NEUROSURGERY 122:317-323(2015).

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