IDH1
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Official Full Name
isocitrate dehydrogenase 1 (NADP+), soluble -
Overview
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. -
Synonyms
Cytosolic NADP isocitrate dehydrogenase;Cytosolic NADP-isocitrate dehydrogenase;ICDH;IDCD;IDH;IDH1;IDHC_HUMAN;IDP;IDPC;Isocitrate dehydrogenase [NADP] cytoplasmic;Isocitrate dehydrogenase 1 (NADP+) soluble;NADP dependent isocitrate dehydrogenase cytosolic;NADP dependent isocitrate dehydrogenase peroxisomal;NADP(+)-specific ICDH;Oxalosuccinate decarboxylase;PICD;Isocitrate dehydrogenase
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Insect Cells
- HEK293
- Mammalian Cells
- Human
- His
- Flag
- DDK&Myc
- Non
- Avi&Fc&His
- GST&His
Involved Pathway
IDH1 involved in several pathways and played different roles in them. We selected most pathways IDH1 participated on our site, such as Citrate cycle (TCA cycle),Glutathione metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | KIT,G6PD,RAF1,PIK3CD,MTOR,MAP2K1,GLS2,SIRT3,NTRK3,NTRK1 |
| Metabolic pathways | LPCAT2,NDUFAB1A,PLA2G2E,PLCB1,PTGS1,PTGESL,POLR3D,MGAT3A,EXT2,UPP1 |
| Glutathione metabolism | GSTT2,LAP3,GSTA2,GPX8,IDH2,GGCT,GPX4B,GSTA3,MGST1,GSTM2 |
| -Oxocarboxylic acid metabolism | GPT2L,AADAT,GOT2,BCAT1,GPT2,IDH3B,ACY1,BCAT2,IDH3G,ACO2 |
| Biosynthesis of amino acids | PRPS1L1,PRPS2,CBS,ALDH18A1,MAT2AL,GPT,PKM2,ENO3,TAT,PKLR |
| Peroxisome | ACOX2,SLC25A17,MLYCD,MPV17L2,PEX5L,PEX11B,ACOX1,PEX26,NOS2A,PEX19 |
| Citrate cycle (TCA cycle) | MDH1AA,CS,OGDHL,SDHDB,IDH3A,PCK1,DLDH,PCK2,OGDHA,PDHA1A |
| Carbon metabolism | GOT2B,GLUD1A,DLAT,HK3,DLST,IDH3B,ACADM,MDH1AA,PFKMB,ENO3 |
Protein Function
IDH1 has several biochemical functions, for example, NAD binding,NADP binding,isocitrate dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH1 itself. We selected most functions IDH1 had, and list some proteins which have the same functions with IDH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | LDB1,MASP1,TRIM37,XDH,SLC30A8,IL17F,ASMT,CRYBB2,ATPIF1B,SMAD2 |
| receptor binding | PSPN,LTA,HAO2,PPP2R4,APP,PTK2B,SELPLG,FGF6A,HAMP,FGG |
| isocitrate dehydrogenase (NADP+) activity | IDH2 |
| NADP binding | GAPDHS,PGD,SPR,HMGCRB,MIOX,GSR,NDOR1,NOX5,CRYZL1,CRYM |
| NAD binding | CYB5R3,GRHPRA,LDHA,PHGDH,IDH3G,ADH4,ME2,AOX3L1,HIBADH,TESCA |
| magnesium ion binding | ATP4A,FOXK2,MAST4,STK36,PPM1AB,ITPK1,IDH3G,SNRK,IMPA1,PKM2 |
Interacting Protein
IDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH1.
gltX;mtfA;CEP57L1;ZHX1;15-deoxy-delta(12,14;ere_dna
Resources
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References
- Bunse, L; Schumacher, T; et al. Proximity ligation assay evaluates IDH1(R132H) presentation in gliomas. JOURNAL OF CLINICAL INVESTIGATION 125:593-606(2015).
- Kawasoe, T; Takeshima, H; et al. Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme. JOURNAL OF NEUROSURGERY 122:317-323(2015).
