ID2

  • Official Full Name

    inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

  • Overview

    The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional;regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA;binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by;suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively;regulating cell differentiation. A pseudogene of this gene is located on chromosome 3.

  • Synonyms

    ID2;inhibitor of DNA binding 2, dominant negative helix-loop-helix protein;DNA-binding protein inhibitor ID-2;bHLHb26;cell growth inhibiting gene 8;GIG8;helix-loop-helix protein ID2;cell growth-inhibiting gene 8;inhibitor of differentiation 2;DNA

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Wheat Germ
  • Mammalian Cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Non
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
ID2-28380TH Recombinant Human ID2 Wheat Germ Human Non 135 amino acids
ID2-2982R Recombinant Rat ID2 Protein Mammalian Cells Rat His
ID2-6560C Recombinant Chicken ID2 Mammalian Cells Chicken His
ID2-7547H Recombinant Human ID2, His-tagged E.coli Human His 1-134aa
ID2-7980M Recombinant Mouse ID2 Protein Mammalian Cells Mouse His
ID2-5311HCL Recombinant Human ID2 293 Cell Lysate HEK293 Human Non
Id2-1208M Recombinant Mouse Id2 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
ID2-245HF Active Recombinant Full Length Human ID2 Protein In Vitro Cell Free System Human Full L. 135 amino acids
ID2-2637R Recombinant Rat ID2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ID2-2637R-B Recombinant Rat ID2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ID2-3063H Recombinant Human ID2 protein, His-SUMO-tagged E.coli Human His&SUMO 1-134aa
ID2-4406M Recombinant Mouse ID2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ID2-4406M-B Recombinant Mouse ID2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ID2 involved in several pathways and played different roles in them. We selected most pathways ID2 participated on our site, such as TGF-beta signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway AMH,CRB1,WTIP,WNT11,PPP2R2A,BMP8A,DLG3,RASSF1,ID1,MPP5
    Transcriptional misregulation in cancer HIST1H3F,BCL2A1A,EYA1,GOLPH3,MDM2,SPINT1,MLL1,CDK14,FOXO1,GRIA3
    Signaling pathways regulating pluripotency of stem cells LIFR,NRAS,HOXB1,WNT2,INHBB,DLX5,ID3,WNT5B,LEFTY2,AKT1
    TGF-beta signaling pathway LFT1,SMAD6,SMAD5,TFDP1A,TGFB3,ACVR1C,SMAD3,BMP7B,SMAD7,GDF7

    Protein Function

    ID2 has several biochemical functions, for example, ion channel binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ID2 itself. We selected most functions ID2 had, and list some proteins which have the same functions with ID2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FCGR2C,JAGN1,PPIF,KEAP1,EIF5A2,CNIH2,IGFN1,HMOX1,EPB41L1,ATF3
    protein dimerization activity TWIST1A,MYCS,OLIG4,HER3,NCOA3,EBF2,CELSR1,MEF2B,ANO4,MESPAB
    ion channel binding KCNQ1,RANGRF,ABCC9,CAV1,ACTN2,FAM115C,YWHAQ,LRRK2,DIAPH1,PRNP

    Interacting Protein

    ID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID2.

    PKD2;TCF3;CCNDBP1;SUV39H1;KDM1A;HSPA5;MAPK3;MAPK1;MAPK8

    Resources

    Research Area

    Cancer Stem Cell Transcription Factors
    Neural Stem Cell Markers
    Natural Killer T (NKT) Cells
    Neural Progenitor Cell Markers
    Dendritic Cell Development

    References

    • Gnidehou, S; Doritchamou, J; et al. Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax. INFECTION AND IMMUNITY 82:2565-2573(2014).
    • Kusama, H; Kobayashi, R; et al. Midazolam inhibits IgE production in mice via suppression of class switch recombination. JOURNAL OF ORAL SCIENCE 56:77-83(2014).

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