ID2
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Official Full Name
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -
Overview
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional;regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA;binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by;suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively;regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. -
Synonyms
ID2;inhibitor of DNA binding 2, dominant negative helix-loop-helix protein;DNA-binding protein inhibitor ID-2;bHLHb26;cell growth inhibiting gene 8;GIG8;helix-loop-helix protein ID2;cell growth-inhibiting gene 8;inhibitor of differentiation 2;DNA
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- Non
- His
- DDK
- Myc
- Avi
- Fc
- SUMO
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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ID2-28380TH | Recombinant Human ID2 | Wheat Germ | Human | Non | 135 amino acids |
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ID2-2982R | Recombinant Rat ID2 Protein | Mammalian Cells | Rat | His |
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ID2-6560C | Recombinant Chicken ID2 | Mammalian Cells | Chicken | His |
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ID2-7547H | Recombinant Human ID2, His-tagged | E.coli | Human | His | 1-134aa |
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ID2-7980M | Recombinant Mouse ID2 Protein | Mammalian Cells | Mouse | His |
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ID2-5311HCL | Recombinant Human ID2 293 Cell Lysate | HEK293 | Human | Non |
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Id2-1208M | Recombinant Mouse Id2 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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ID2-245HF | Active Recombinant Full Length Human ID2 Protein | In Vitro Cell Free System | Human | Full L. 135 amino acids |
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ID2-2637R | Recombinant Rat ID2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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ID2-2637R-B | Recombinant Rat ID2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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ID2-3063H | Recombinant Human ID2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-134aa |
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ID2-4406M | Recombinant Mouse ID2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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ID2-4406M-B | Recombinant Mouse ID2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ID2 involved in several pathways and played different roles in them. We selected most pathways ID2 participated on our site, such as TGF-beta signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Transcriptional misregulation in cancer | TCF3,ETV6,PLAT,HIST1H3G,NCOR1,HDAC1,HIST2H3C2,BCL2A1A,MAF,NFKB1 |
TGF-beta signaling pathway | SMAD3,RHOAC,TGIF1,THBS1,ID2B,TGFBR1,BMPR1BB,GDF5,SKP1,ID3 |
Hippo signaling pathway | CRB2,BMPR1A,TEAD4,PARD6A,GDF7,SMAD1,WNT5A,TCF7,CDH1,PPP2R2C |
Signaling pathways regulating pluripotency of stem cells | PIK3CG,MEIS1,HNF1A,PIK3R1,BMPR2,WNT10B,FGFR3,FGFR4,TBX3,MAPK1 |
Protein Function
ID2 has several biochemical functions, for example, ion channel binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ID2 itself. We selected most functions ID2 had, and list some proteins which have the same functions with ID2. You can find most of the proteins on our site.
Function | Related Protein |
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ion channel binding | FGF13,AKAP9,RIMS1,CALM2,USP10,DLG1,SRC,FXYD1,CALM1,KCND3 |
protein dimerization activity | DAO1,ID2B,PRDX5,NPAS1,TFE3,CLOCK,HIF1AB,MTOR,SCXB,PRKRIR |
protein binding | RCOR3,FEM1C,XIRP2,POLDIP3,RIOK3,JAM3,NSMCE4A,CRP,PPARD,USP25 |
Interacting Protein
ID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID2.
PKD2;TCF3;CCNDBP1;SUV39H1;KDM1A;HSPA5;MAPK3;MAPK1;MAPK8
Resources
Research Area
Cancer Stem Cell Transcription FactorsNeural Stem Cell Markers
Natural Killer T (NKT) Cells
Neural Progenitor Cell Markers
Dendritic Cell Development
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References
- Gnidehou, S; Doritchamou, J; et al. Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax. INFECTION AND IMMUNITY 82:2565-2573(2014).
- Kusama, H; Kobayashi, R; et al. Midazolam inhibits IgE production in mice via suppression of class switch recombination. JOURNAL OF ORAL SCIENCE 56:77-83(2014).