ICA1
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Official Full Name
islet cell autoantigen 1, 69kDa -
Overview
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogrens syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. -
Synonyms
ICA1;islet cell autoantigen 1, 69kDa;islet cell autoantigen 1 (69kD);islet cell autoantigen 1;ICAp69;69 kDa islet cell autoantigen;Diabetes mellitus type I autoantigen;ICA 1;ICA69;ICA69_HUMAN;Islet cell autoantigen 1 69kDa;Islet cell autoantigen 1 isoform;Islet cell autoantigen p69;OTTHUMP00000200933;OTTHUMP00000200934;OTTHUMP00000200941;OTTHUMP00000200993;p69
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- HEK293
- Mammalian Cells
- E.coli
- Wheat Germ
- Yeast
- Myc&DDK
- His
- GST
- His&S
- Non
- His&Fc&Avi
- Flag
Involved Pathway
ICA1 involved in several pathways and played different roles in them. We selected most pathways ICA1 participated on our site, such as Type I diabetes mellitus, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type I diabetes mellitus | CD80,HSPD1,CPE,H2-Q10,PTPRN2,FAS,INS1,HLA-A,LTA,IL1B |
Protein Function
ICA1 has several biochemical functions, for example, molecular_function,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICA1 itself. We selected most functions ICA1 had, and list some proteins which have the same functions with ICA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | GM4216,CCDC90A,UACA,VMN1R111,LRIG2,VMN1R165,SPON1A,GM4836,GM9994,TMEM125B |
| protein domain specific binding | CRB3,TFDP1,EFS,WNT3A,GUSB,CASP2,VAPA,FOXA2,MYO1D,SCN5A |
| protein binding | CTNNB2,THOP1,GBAS,COX5A,KLC4,PTPRB,NOL6,FOXR2,SYNM,SESN2 |
Interacting Protein
ICA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICA1.
MBD3;RAB2A;CCDC28A;CCDC28A;RAB2B;ING5;STK16;MYC
Resources
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References
- Chapal, N; Peraldi-Roux, S; et al. Human anti-thyroid peroxidase single-chain fragment variable of Ig isolated from a combinatorial library assembled in-cell: Insights into the in vivo situation. JOURNAL OF IMMUNOLOGY 164:4162-4169(2000).
