HSD17B2
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 2 -
Overview
Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene. -
Synonyms
HSD17B2;hydroxysteroid (17-beta) dehydrogenase 2;estradiol 17-beta-dehydrogenase 2;HSD17;SDR9C2;short chain dehydrogenase/reductase family 9C;member 2;17 beta HSD 2;20 alpha HSD;20 alpha hydroxysteroid dehydrogenase;E2DH;Microsomal 17 beta hydroxysteroid dehydrogenase;Testosterone 17 beta dehydrogenase;20-alpha-HSD;17-beta-HSD 2;OTTHUMP00000174979;testosterone 17-beta-dehydrogenase;20 alpha-hydroxysteroid dehydrogenase;17-beta-hydroxysteroid dehydrogenase type 2;microsomal 17-beta-hydroxysteroid dehydrogenase;short chain dehydrogenase/reductase family 9C, member 2;EDH17B2
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Cynomolgus
- Mouse
- Mus musculus
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- In Vitro Cell Free System
- Mammalian cells
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&GST
- Flag
Involved Pathway
HSD17B2 involved in several pathways and played different roles in them. We selected most pathways HSD17B2 participated on our site, such as Steroid hormone biosynthesis,Metabolic pathways,Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UGT2A2,UPRT,ACSS3,COQ3,AMPD1,IDUA,PDXP,PHOSPHO1,NDUFA9A,ADSS |
| Ovarian steroidogenesis | LHB,PLA2G4C,HSD3B6,IGF1,Adcy4,HSD17B1,HSD17B7,PLA2G4A,GNAS,INS2 |
| Steroid hormone biosynthesis | UGT5G1,CYP3A41B,CYP3A65,SULT1E1,UGT1A4,CYP2C45,CYP3A7,STS,CYP11C1,CYP2C55 |
Protein Function
HSD17B2 has several biochemical functions, for example, 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity,estradiol 17-beta-dehydrogenase activity,testosterone dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B2 itself. We selected most functions HSD17B2 had, and list some proteins which have the same functions with HSD17B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| estradiol 17-beta-dehydrogenase activity | HSD17B10,HSD17B6,AKR1B15,RDH8A,AKR1C6,HSD17B14,HSD17B7,RDH8,HSD17B12A,HSD17B8 |
| testosterone dehydrogenase (NAD+) activity | HSD17B1,H2-KE6,HSD17B8,DHRS9,HSD17B6,AKR1C3 |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | AKR1C6 |
Interacting Protein
HSD17B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B2.
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References
- Cheng, YH; Imir, A; et al. SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. BIOLOGY OF REPRODUCTION 75:605-614(2006).
