HPSE
-
Official Full Name
heparanase -
Overview
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
HPSE;heparanase;HPA;HPA1;HPR1;HSE1;HPSE1;heparanase-1;endo-glucoronidase
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- CHO
- Mammalian Cells
- E.coli
- Wheat Germ
- Myeloma
- HEK293
- Non
- His
- GST
- His&T7
- Avi&Fc&His
- His&Myc
Involved Pathway
HPSE involved in several pathways and played different roles in them. We selected most pathways HPSE participated on our site, such as Glycosaminoglycan degradation,Glycosaminoglycan metabolism,HS-GAG degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan degradation | GLB1,HEXA,HEXB,HPSE2,SGSH,GALNS,GNS,GNSA,NAGLU,IDS |
| Metabolic pathways | PRPS1A,ATP5IA,GALNT13,NDUFA6,RRM2,AKR1C3,COX5B,CYP2C8,CKB,AOX4 |
| HS-GAG degradation | GPC1A,GPC5A,GPC1B,Gpc2,GLB1L |
| Metabolism of carbohydrates | CHP,ST3GAL3A,SLC35D2,SLC26A1,DSEL,KHK,EPM2A,SLC5A4,Gpc2,CHST9 |
| Glycosaminoglycan metabolism | CSPG5B,HS3ST6,GPC5A,HAS3,OGN,SLC26A1,KIAA1199,B3GAT2,HAS1,SLC35B2 |
| Heparan sulfate/heparin (HS-GAG) metabolism | CSPG5B,B3GAT2,HS3ST6,GPC1B,SLC35D2,B4GALT7,MAPK1IP1L,GPC5A,GLB1L,GPC1A |
| Metabolism | ST3GAL3A,AK8,SLC35D1A,CYP3A7-CYP3AP1,MED9,GLTPD1,C2orf56,GPHN,FAM213B,SLC25A32B |
| Proteoglycans in cancer | FAS,NANOG,SDC2,DDX5,HPSE2,RAC1,WNT7A,SRC,TRP53,GAB1 |
Protein Function
HPSE has several biochemical functions, for example, beta-glucuronidase activity,heparanase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPSE itself. We selected most functions HPSE had, and list some proteins which have the same functions with HPSE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-glucuronidase activity | GUSB |
| protein binding | CCDC167,LILRB2,CDH2,GOSR2,GNB2L1,TPCN2,KITLG,FMO4,PDK3,KTI12 |
| syndecan binding | CHRD,SEMA5A,TNC,SDCBP |
| protein dimerization activity | ZBED1,MESPBA,ASCL5,NUP210,KIF9,STAT3,OLIG4,SREBF2,CLOCKA,ATM |
Interacting Protein
HPSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPSE here. Most of them are supplied by our site. Hope this information will be useful for your research of HPSE.
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References
- Zhang, J; Yang, JM; et al. Multiple antigenic polypeptide composed of heparanase B-cell epitopes shrinks human hepatocellular carcinoma in mice. ONCOLOGY REPORTS 33:1248-1256(2015).
- Zhang, J; Yang, JM; et al. Synthesized Multiple Antigenic Polypeptide Vaccine Based on B-Cell Epitopes of Human Heparanase Could Elicit a Potent Antimetastatic Effect on Human Hepatocellular Carcinoma In Vivo. PLOS ONE 8:-(2013).
