GPC1
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Official Full Name
glypican 1 -
Overview
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage.These proteins may play a role in the control of cell division and growth regulation. -
Synonyms
GPC1;glypican 1;glypican-1;glypican;glypican proteoglycan 1;FLJ38078;glypican1;GPC 1;GPC1_HUMAN;Secreted glypican-1;OTTHUMP00000164497;OTTHUMP00000201548
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- HEK293
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- E.coli
- His
- Non
- His&GST&Myc
- His&Fc&Avi
- GST
- Fc
Involved Pathway
GPC1 involved in several pathways and played different roles in them. We selected most pathways GPC1 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | GAB1,WNT2B,PRKACA,PLAUR,TGFB2,PTK2,HIF1A,SDC1,PIK3CA,SLC9A1 |
Protein Function
GPC1 has several biochemical functions, for example, copper ion binding,fibroblast growth factor binding,heparan sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPC1 itself. We selected most functions GPC1 had, and list some proteins which have the same functions with GPC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor binding | RPS2,GLG1,THBS1,SCN5A,S100A13,PTPRZ1,FGFBP3,CEP57,FGFR2,FIBPA |
| copper ion binding | LOXL5A,HEPH,METTL17,ANG,MOXD1,S100A12,LOXL5B,HIST2H3A,LOXL2A,F5 |
| laminin binding | NCL,AGRN,BCAM,LYPD5,TINAGL1,ITGA3,THBS1,ITGB1,ITGA7,ADAM9 |
| heparan sulfate proteoglycan binding | Itgam&Itgb2,SEMA5A,SLIT2,GPC1A,AGRN,GPC5,GPC5A,Gpc2,HPSE2,GPC4 |
Interacting Protein
GPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPC1.
TDGF1;PECAM1;FSTL1;Cbx1;Prkci;Mad2l1
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References
- Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
- Kayed, H; Kleeff, J; et al. Correlation of glypican-1 expression with TGF-beta, BMP, and activin receptors in pancreatic ductal adenocarcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY 29:1139-1148(2006).
- RUSSELL, DA; SACHS, MM; et al. THE MAIZE CYTOSOLIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE FAMILY - ORGAN-SPECIFIC EXPRESSION AND GENETIC-ANALYSIS. MOLECULAR & GENERAL GENETICS 229:219-228(1991).
