GOT2
-
Official Full Name
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) -
Overview
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively.GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. -
Synonyms
GOT2;glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2);aspartate aminotransferase, mitochondrial;KAT4;KATIV;kynurenine aminotransferase IV;mitAAT;ASPATA;FABP pm;Got 2;MGC102129;MGC115763;mitochondrial;AATM_HUMAN;AL022787;Aspartate aminotransferase;Aspartate aminotransferase 2;EC 2.6.1.1;FABP 1;FABP-1;FABPpm;Fatty acid binding protein;Fatty acid-binding protein;FLJ40994;Glutamate oxaloacetate transaminase 2;Glutamate oxaloacetate transaminase 2, mitochondrial;Glutamate oxaloacetate transaminase, mitochondrial;Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2);mAspAT;Mitochondrial aspartate aminotransferase;OTTMUSP00000017748;Plasma membrane fatty acid binding protein;Plasma membrane-associated fatty acid-binding protein;Transaminase A
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Chicken
- Bovine
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&SUMO
- His&Fc&Avi
- N-His&C-Myc
- GST
Involved Pathway
GOT2 involved in several pathways and played different roles in them. We selected most pathways GOT2 participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GOT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ADSSL1,GLUD2,GPT,ADSL,RIMKLB,DDO,NAT8L,ASS1,PPAT,CPS1 |
| Fat digestion and absorption | DGAT1,PLA2G1B,PLA2G12B,PPAP2B,ABCA1,SCARB1,AGPAT1,PLA2G2A,MOGAT2,PLA2G2E |
| Tyrosine metabolism | FAH,HGD,COMTB,ADH2-1,ALDH3B2,GOT2A,ADH1,AOX2P,ADH2-2,AOX3 |
| Phenylalanine metabolism | HPD,MIF,HPDB,AOC2,ALDH1A3,PAH,ALDH3A1,GOT2A,TAT,KEG1 |
| Cysteine and methionine metabolism | MAT2B,MDH1AA,MDH2,SDSL,AHCY,TAT,AGXT2,DNMT3AB,GOT2A,BCAT1 |
| Carbon metabolism | PFKM,AMT,CS,IDH3B,PHGDH,ALDOCB,ACSS1,AGXT,TPI1,ALDOA |
| Arginine and proline metabolism | SMOX,GOT2B,PYCR1B,Ckmm,NOS2,P4HA1B,ALDH3A2,PYCR1A,CNDP1,ALDH9A1B |
| Phenylalanine, tyrosine and tryptophan biosynthesis | TAT,GOT2B,PAH,GOT1,GOT2A,IL4I1 |
| Metabolic pathways | AOX1,AKR1C4,CYP2C50,ALPPL2,SPRA,RDH8,CES1,DAO.3,DNMT3AB,FUT4 |
Protein Function
GOT2 has several biochemical functions, for example, L-aspartate:2-oxoglutarate aminotransferase activity,L-phenylalanine:2-oxoglutarate aminotransferase activity,amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GOT2 itself. We selected most functions GOT2 had, and list some proteins which have the same functions with GOT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipid binding | PLA2G2A,SNCA,APOM,PLA2G7,APOA1,PACSIN1A,ANXA1,ABCG1,SHC1,F3 |
| kynurenine-oxoglutarate transaminase activity | CCBL2,CCBL1,AADAT |
| L-phenylalanine:2-oxoglutarate aminotransferase activity | GOT1,GOT2B,TAT,GOT2A |
| amino acid binding | TPH1B,TPH1A,TPH2,PAH,TH,AGXT,SHMT2,DDAH1,TPH1,OTC |
| L-aspartate:2-oxoglutarate aminotransferase activity | GOT1L1,GOT1,GOT2A,GOT2B |
| identical protein binding | CRYAB,GPR50,APOA1,CORO1B,CD74,PPPDE2,VCP,SOX10,APLP2,LCK |
| protein homodimerization activity | BAX,MID1,STK4,BCL2,SRR,IMPA2,PDXK,MIXL1,RIPK2,UGT1A4 |
| pyridoxal phosphate binding | TAT,GCAT,MARC2,HINT2,CTH,AGXT2L1,SPTLC2B,SDS,PYGM,ACCS |
| poly(A) RNA binding | CPSF6,ZFP207,BZW1,BICC1,DDX42,MRPS23,TPT1,HMGB3,SF3B14,G3BP1 |
Interacting Protein
GOT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GOT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GOT2.
EIF1B;BCAR3;GH1;EPB41;VDAC1;MCC;CDK2;MPG;HLA-B;HLA-C;ARF6;CCNA1;PAK2;Bles03;ATG5;CTNNBIP1;FTSJ1;TNIK;PACSIN3;PRKAB1
Resources
Related Services
Related Products
References
- Han, QA; Cai, T; et al. Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. BMC BIOCHEMISTRY 11:-(2010).
- Han, Q; Cai, T; et al. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. CELLULAR AND MOLECULAR LIFE SCIENCES 67:353-368(2010).
