GOT1
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Official Full Name
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) -
Overview
Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. -
Synonyms
GOT1;glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1);aspartate aminotransferase, cytoplasmic;transaminase A;growth-inhibiting protein 18;glutamate oxaloacetate transaminase 1;GIG18;ASTQTL1
Recombinant Proteins
- Human
- Porcine
- Zebrafish
- Rat
- Mouse
- Cynomolgus
- Cattle
- Chicken
- Schizosaccharomyces pombe
- E.coli
- Liver
- Porcine Heart
- Mammalian Cell
- E.Coli or Yeast
- Yeast
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- Human Heart
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
Involved Pathway
GOT1 involved in several pathways and played different roles in them. We selected most pathways GOT1 participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GOT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine and proline metabolism | P4HA1,NOS3,DAO,AMD1,NOS1,ALDH18A1,CKB,CKMT2,CKMA,OAT |
| Alanine, aspartate and glutamate metabolism | CPS1,GAD1B,IL4I1,GOT2,GPT2L,ASS1,GAD1,ADSS,AGXT2,GAD2 |
| -Oxocarboxylic acid metabolism | GOT2B,IDH3G,ACY1,IDH2,GPT2,GOT2,GPT,ACO1,IDH3A,BCAT2 |
| Arginine biosynthesis | GLUD2,GOT2,ASL,GLULC,NOS2B,ybaS,GLUD1,ASL2,GLSA,GPT |
| Tyrosine metabolism | FAHD1,HPDA,AOX4,AOC3,TYR,ADH1,HPD,MIF,HGD,DCT |
| Phenylalanine metabolism | AOC3,AOC2,TAT,ALDH1A3,MAOA,GOT2A,GOT2B,ALDH3B1,HPDB,HPDA |
| Phenylalanine, tyrosine and tryptophan biosynthesis | GOT2B,GOT2A,IL4I1,GOT2,PAH,TAT |
| Cysteine and methionine metabolism | MRI1,AHCYL2,AHCY,MDH1AA,LDHA,LDHBB,MDH2,BHMT,MAT2A,GSS |
| Metabolic pathways | UQCR10,PANK1B,GALNT11,PANK2,GCDH,GLSA,ALDH5A1,TKT,PGLS,ATP6V1E1B |
Protein Function
GOT1 has several biochemical functions, for example, L-aspartate:2-oxoglutarate aminotransferase activity,L-cysteine:2-oxoglutarate aminotransferase activity,L-phenylalanine:2-oxoglutarate aminotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GOT1 itself. We selected most functions GOT1 had, and list some proteins which have the same functions with GOT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | PYGM,GPT2,MOCOS,PYGB,TAT,SDS,PYGMB,AGXT2,CSAD,PDXK |
| identical protein binding | KRTAP10-5,MYOM1,DAPK3,RIPK1,DPP9,MMP9,MAP3K11,RGMB,TPD52L1,EGFR |
| L-aspartate:2-oxoglutarate aminotransferase activity | GOT1L1,GOT2A,GOT2,GOT2B |
| phosphatidylserine decarboxylase activity | PISD |
| carboxylic acid binding | AKR1C21,HMGCL,GRHPR,PCK1,AKR1C2,HIF1AN |
| L-phenylalanine:2-oxoglutarate aminotransferase activity | GOT2B,GOT2A,GOT2,TAT |
Interacting Protein
GOT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GOT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GOT1.
HLA-B;TNIK;EGFR;ABI3BP;TMEM120A;ere_dna
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