GNRHR
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Official Full Name
gonadotropin-releasing hormone receptor -
Overview
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GNRHR;gonadotropin-releasing hormone receptor;HH7;GRHR;LRHR;LHRHR;GNRHR1;gnRH-R;gnRH receptor;luliberin receptor;type I GnRH receptor;leutinizing-releasing hormone receptor;leutinizing hormone releasing horomone receptor;gonadotropin-releasing hormone (type 1) receptor 1
Recombinant Proteins
- Chicken
- Rat
- Mouse
- Human
- Dog
- Sus scrofa (Pig)
- Bos mutus grunniens (Wild yak) (Bos grunniens)
- Horse
- Bovine
- Trichosurus vulpecula (Brush-tailed possum)
- Sheep
- Mus musculus
- Guinea pig
- Octopus vulgaris (Common octopus)
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Flag
- His&Fc&Avi
- GST
Involved Pathway
GNRHR involved in several pathways and played different roles in them. We selected most pathways GNRHR participated on our site, such as Neuroactive ligand-receptor interaction,GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNRHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRM6,TAAR14A,TAAR12J,TACR3A,GHRHRL,TAAR10D,TRY,GNRHR1,PTGER2B,TAAR8C |
| GnRH signaling pathway | GNA15.1,MAP2K4B,GNRH1,CALM,PRKACAA,MAPK14B,SOS1,ATF4,PRKCBB,ELK1 |
Protein Function
GNRHR has several biochemical functions, for example, gonadotropin-releasing hormone receptor activity,peptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNRHR itself. We selected most functions GNRHR had, and list some proteins which have the same functions with GNRHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide binding | AVPR2,CSNK1D,TPP1,AVPR1A,NPFFR1L3,ERAP1,NPFFR2.1,OXTRL,CALR,RPS6KB2 |
| gonadotropin-releasing hormone receptor activity | GNRHR2,GPR173,GNRHR1,GNRHR4,GNRHR3 |
Interacting Protein
GNRHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNRHR here. Most of them are supplied by our site. Hope this information will be useful for your research of GNRHR.
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References
- Cordeddu, L; Bergvall, M; et al. Severe gastrointestinal dysmotility developed after treatment with gonadotropin-releasing hormone analogs. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 50:291-299(2015).
- Kadokawa, H; Pandey, K; et al. Gonadotropin-releasing hormone (GnRH) receptors of cattle aggregate on the surface of gonadotrophs and are increased by elevated GnRH concentrations. ANIMAL REPRODUCTION SCIENCE 150:84-95(2014).
