GM2A
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Official Full Name
GM2 ganglioside activator -
Overview
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. -
Synonyms
GM2A;GM2 ganglioside activator;GM2 ganglioside activator protein;ganglioside GM2 activator;cerebroside sulfate activator protein;SAP 3;sphingolipid activator protein 3;Ganglioside GM2 activator isoform short;Ganglioside GM2 activator precursor;GM2 AP;GM2-AP;GM2AP;OTTHUMP00000160619;SAP-3;SAP3;SAP3_HUMAN;Shingolipid activator protein 3
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- Non
- Flag
- His&SUMO
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GM2A involved in several pathways and played different roles in them. We selected most pathways GM2A participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | CTSE,ASAH1A,SGSH,AP1S3B,ACP5B,GNSA,FAM49BA,CTSW,TCEAL4,AP1M1 |
Protein Function
GM2A has several biochemical functions, for example, beta-N-acetylgalactosaminidase activity,lipid transporter activity,phospholipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GM2A itself. We selected most functions GM2A had, and list some proteins which have the same functions with GM2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid transporter activity | VTG4,APOM,CETP,MTP,VTG6,APOA1A,APOD,RFT1,APOF,APOA4 |
| phospholipase activator activity | ARHGAP6,CCL5,APOC2,CCL8,CCL3,PDPK1 |
Interacting Protein
GM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of GM2A.
pi3p;GABARAPL2
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References
- Molnar, J; Nagy, T; et al. Genome sequencing and analysis of Mangalica, a fatty local pig of Hungary. BMC GENOMICS 15:-(2014).
- Sinici, I; Yonekawa, S; et al. In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside. PLOS ONE 8:-(2013).
