GIPR
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Official Full Name
gastric inhibitory polypeptide receptor -
Overview
Gastric Inhibitory Polypeptide Receptor is a member of the G protein-coupled receptor (GPCR, or GPR) family (subfamily Gastric inhibitory polypeptide). Members of this family contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Gastric inhibitory polypeptide receptor is a receptor for gastric inhibitory polypeptide (GIP), this is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food- dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries. -
Synonyms
GIPR;gastric inhibitory polypeptide receptor;PGQTL2;GIP-R;glucose-dependent insulinotropic polypeptide receptor;MGC126722;GIP;Gastric Inhibitory Peptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Mus musculus
- Mesocricetus auratus
- E.coli
- HEK293T
- HEK293
- Mammalian Cell
- In vitro E. coli expression system
- Insect Cell
- E.coli expression system
- GST
- Non
- His
- Myc&DDK
- His&Flag
- His&Myc
- His&MBP&Avi
- His&Avi
- His&Fc&Avi
Involved Pathway
GIPR involved in several pathways and played different roles in them. We selected most pathways GIPR participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | SSTR1,GRM3,DRD4-RS,MC5RA,GRM6A,TAAR12F,GABRG1,RXFP1,TRHR2,HTR2C |
| cAMP signaling pathway | CAMK2D,PDE4C,VAV3,PRKACG,CAMK2A,F2R,CNGA4,RYR2,EP300,BRAF |
Protein Function
GIPR has several biochemical functions, for example, gastric inhibitory peptide receptor activity,peptide hormone binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GIPR itself. We selected most functions GIPR had, and list some proteins which have the same functions with GIPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide hormone binding | INHBA,CRHR2,MAS1,NPR3,GALR1,GALR2,AGTR1A,AVPR1A,NPR2,PTH1RB |
| transmembrane signaling receptor activity | NRXN2,OR4C13,KLRC3,NRXN3,FZD3B,KLRB1,GPR133,Fzd4,BAI2,TLR4 |
Interacting Protein
GIPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GIPR.
Resources
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References
- Chen, S; Okahara, F; et al. Increased GIP signaling induces adipose inflammation via a HIF-1 alpha-dependent pathway and impairs insulin sensitivity in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 308:E414-E425(2015).
- Keyhani-Nejad, F; Irmler, M; et al. Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice. DIABETOLOGIA 58:374-383(2015).
Reviews
Q&As
This protein encodes Gly26-Gln138 [Accession # P48546.1] and was fused with Fc tag at C terminus. Due to the high production cost, we do not have a free sample. We are happy to provide 10% OFF to support your testing. Let us know if you would like to proceed.