FOXP1
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Official Full Name
forkhead box P1 -
Overview
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
FOXP1;forkhead box P1;QRF1;12CC4;hFKH1B;HSPC215;forkhead box protein P1;glutamine-rich factor 1;fork head-related protein like B
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Mouse
- E.coli
- Wheat Germ
- Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Flag
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FOXP1 involved in several pathways and played different roles in them. We selected most pathways FOXP1 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | DNMT3A,NFKB1,MAP2K2,ITGA5,PLAU,FGFR3,CYP24A1,STMN1,SOX4,TP53 |
Protein Function
FOXP1 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,androgen receptor binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXP1 itself. We selected most functions FOXP1 had, and list some proteins which have the same functions with FOXP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | JUNBB,ATF4B2,FOXI2,PEG3,SOX8,FOXN1,JUNB,FOXE3,BMPR1A,MKX |
| sequence-specific DNA binding | ATF4B2,CHES1,POU3F3A,CDX1B,SPDEF,ZNF263,RARGA,SLAMF7,DLX2B,MKXA |
| metal ion binding | EGR2A,GTF3A,OGDH,PCGF5A,PLAGL1,ARL1,MOB2,ARHGEF28,RC3H1,ZFP354B |
| protein binding | KLRC1,VAV3,CCDC109A,KIF5A,USP22,NEK3,KIFAP3,AHNAK,CCDC108,FAM134C |
| androgen receptor binding | WIPI1,PRKCB,GRIP1,PRKCBB,NSD1,Ar,NCOA4,SMARCA4,DAXX,TGFB1I1 |
Interacting Protein
FOXP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXP1.
LRRK1;IL3RA;alaS;mglA3;q7cia4_yerpe;opuD;ppk;gabD;mdtB;arre2_element_mouse_il2_promoter;MYC
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References
- Hu, ZH; Zhu, LC; et al. The expression and correlation between the transcription factor FOXP1 and estrogen receptors in epithelial ovarian cancer. BIOCHIMIE 109C:42-48(2015).
- Gringhuis, SI; Kaptein, TM; et al. Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production. NATURE COMMUNICATIONS 5:-(2014).
