FASN
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Official Full Name
fatty acid synthase -
Overview
Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN geneFatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next. -
Synonyms
FASN;fatty acid synthase;FAS;SDR27X1;short chain dehydrogenase/reductase family 27X;member 1;short chain dehydrogenase/reductase family 27X, member 1;OA-519;MGC14367;MGC15706
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cells
- Insect Cells
- His
- DDK&Myc
- GST
- His&Myc
- Non
- Avi&Fc&His
- Flag
- GST&His
Involved Pathway
FASN involved in several pathways and played different roles in them. We selected most pathways FASN participated on our site, such as Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty Acid Biosynthesis | MCAT,ACSL4A,ACSL3B,ECHDC3,ECHDC2,ACSL1,ACACB,OXSM,ACSL4B,ACAA2 |
| Fatty acid metabolism | ACAA1,ACADSB,ACSL1B,ACSL4A,ACSL4,ACSBG1,ACAA2,ELOVL5,ELOVL2,TECR |
| Insulin signaling pathway | MAPK10,CALM1A,HK1,SOS1,PRKAR2AA,CALM1B,MAP2K2B,PTPRF,IKBKB,INS2 |
| Metabolic pathways | GLUL,DOLK,AGXT2L2,DNMT3B,GAPDH,PLA2G10,PAFAH1B1B,Akr1b3,CYP21A1,ATP5L |
| AMPK signaling pathway | AKT1S1,G6PC2,PIK3R2,RAB10,PPP2R2B,LEP,Scd1,CFTR,SLC2A4,AKT3 |
Protein Function
FASN has several biochemical functions, for example, 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity,3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FASN itself. We selected most functions FASN had, and list some proteins which have the same functions with FASN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADPH binding | DHFR,CBR3,CBR4,CRYZ,MTRR,GRHPR,HMGCR,KCNAB1,DECR1,QDPR |
| palmitoyl-[acyl-carrier-protein] hydrolase activity | OLAH |
| myristoyl-[acyl-carrier-protein] hydrolase activity | OLAH |
| protein homodimerization activity | CR2,PRTFDC1,NKX2-5,BAXB,OXCT1,ENO3,ACCS,RENBP,AMBP,MCL1 |
| drug binding | GABRA1,CHRNA2,TLR8,P2RX2,HTR1B,PDE10A,DRD2,GPR30,GLRB,GRIK1 |
| 3-oxoacyl-[acyl-carrier-protein] synthase activity | OXSM |
| poly(A) RNA binding | SRRT,RIMS1,PPRC1,NOL6,TXN,ZCCHC6,RBM10,RPL35A,MACF1,KHDRBS3 |
| protein binding | NKX3-1,KHK,MAPKAPK2,SLC9A3,DAXX,IL1R1,AP4M1,GPN1,ZNF614,DNAJA3 |
| [acyl-carrier-protein] S-malonyltransferase activity | MCAT |
Interacting Protein
FASN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASN here. Most of them are supplied by our site. Hope this information will be useful for your research of FASN.
q99ib8-pro_0000045603;ILK;YWHAZ;NFKB2;MAP3K1;Bles03;NDRG1;MAP3K3;IKBKG;p29991-pro_0000308465;AKT1;EWSR1;PRR12;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
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References
- Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).
- Zaytseva, YY; Elliott, VA; et al. Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. CARCINOGENESIS 35:1341-1351(2014).
