EZH2
-
Official Full Name
enhancer of zeste homolog 2 (Drosophila) -
Overview
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] -
Synonyms
EZH2;enhancer of zeste homolog 2 (Drosophila);WVS;ENX1;EZH1;KMT6;WVS2;ENX-1;EZH2b;KMT6A;histone-lysine N-methyltransferase EZH2;lysine N-methyltransferase 6
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Insect Cells
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Sf9 Cells
- In Vitro Cell Free System
- Yeast
- GST
- His
- Flag&His
- GST&His
- DDK&Myc
- Non
- Avi&Fc&His
- Flag
Involved Pathway
EZH2 involved in several pathways and played different roles in them. We selected most pathways EZH2 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EZH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | PIK3CA,THBS1,ITGB3,IGF2BP1,WNT3,Pdgfa&Pdgfb,MMP9,TIMP3,ERBB3,TNC |
Protein Function
EZH2 has several biochemical functions, for example, DNA binding,chromatin DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EZH2 itself. We selected most functions EZH2 had, and list some proteins which have the same functions with EZH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin DNA binding | FOXC2,GRHL3,XBP1,H2AFY2,GRHL1,PRDM14,HIST1H1A,THRA,AASS,RXRA |
| histone methyltransferase activity | PRMT2,PRMT1,CARM1,SUV39H1,PRDM13,EED,SUZ12,PRMT6 |
| protein binding | HSPB11,SYTL2,RORB,TRIM24,CD300LD,EPCAM,SNX2,KLRB1B,C20orf195,DCX |
| DNA binding | LIG1,ZNF285A,ISL2B,ZNF443,SOX1B,IRX4B,ARID1AA,H1FNT,ZFP354A,FOXE1 |
| core promoter binding | E2F1,NOTCH1,MED1,IFI203,PYDC3,FOXP3,NEUROG3,CRY1,NKX3,NONO |
| histone methyltransferase activity (H3-K27 specific) | WHSC1L1,EHMT1,EHMT2 |
| protein-lysine N-methyltransferase activity | SMYD2A,METTL8,TRMT10B,RNMTL1B,PRDM12,FAM86A,METTL21D,METTL7B,FAM119A,VCPKMT |
| histone-lysine N-methyltransferase activity | SUV39H1A,PRDM6,KMT2A,AAAS,WBP7,SMYD2B,SETDB1A,PRDM9,MLL1,SMYD1 |
| chromatin binding | URI1,ATAD2,PRIMPOL,SMARCD3,SMARCD1,POLA1,SSRP1,TOX3,NKX2,GATA5 |
Interacting Protein
EZH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EZH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EZH2.
SUZ12;EED
Resources
Research Area
Histone MethyltransferaseEpigenetics and EMT
Melanoma Biomarkers
Prostate Cancer Biomarkers
Related Services
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References
- Alberghini, F; Petrocelli, V; et al. An epigenetic view of B-cell disorders. IMMUNOLOGY AND CELL BIOLOGY 93:253-260(2015).
- Floris, I; Descamps, B; et al. Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:664-674(2015).
