ENO2
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Official Full Name
enolase 2 (gamma, neuronal) -
Overview
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008] -
Synonyms
ENO2;enolase 2 (gamma, neuronal);NSE;HEL-S-279;gamma-enolase;neural enolase;neuron-specific enolase;neurone-specific enolase;neuron specific gamma enolase;2-phospho-D-glycerate hydrolyase;2-phospho-D-glycerate hydro-lyase;epididymis secretory protein Li 279
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- E.coli
- HeLa, COS7
- Mammalian Cell
- Human
- Wheat Germ
- human Brain
- HEK293
- HEK293 cells
- Mammalian cells
- In Vitro Cell Free System
- E. coli
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
ENO2 involved in several pathways and played different roles in them. We selected most pathways ENO2 participated on our site, such as Glycolysis / Gluconeogenesis,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | NOX1,PIK3CD,CAMK2A,HK2,PIK3CG,ENO1,PIK3R3,IFNG,TF,MAP2K1 |
| Biosynthesis of amino acids | ALDOB,MAT1A,PYCR2,CPS1,PKMB,TPI1A,IDH3G,GPT,ENO3,GOT2 |
| Glycolysis / Gluconeogenesis | PKM,PDHA1,PGAM1A,ADH1,ADH2-1,GPI,ALDOAB,ALDH3A2,PGAM1,LDHBB |
| Carbon metabolism | PGK2,PGAM1B,PKMB,FH,PFKMB,GPI,FBP1B,GOT2,IDH1,SUCLA2 |
| RNA degradation | PAPD7,CNOT7,HSPA9,PABPC4,EXOSC3,EXOSC4,PAN3,PARN,EXOSC5,CNOT4 |
| Metabolic pathways | CDS2,APRT,LDHAL6A,NDUFA6,ATP6V0E1,UGP2B,POLA1,SDHD,PPCDC,ASAH1B |
Protein Function
ENO2 has several biochemical functions, for example, lyase activity,magnesium ion binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ENO2 itself. We selected most functions ENO2 had, and list some proteins which have the same functions with ENO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | GALNT6,CYP8B2,EIF2S2,HDAC8,PDE8A,ARHGEF28,FTR54,PRDM12B,ATP8A1,ZNFX1 |
| lyase activity | ECHDC2,AMD2,AGXT2L2,NPR1A,GLDC,HOGA1,IRG1L,PTGES2,ALDOAB,TYW1B |
| protein homodimerization activity | USF2,FZD1,SPATA24,ASCL1,BMPR1A,NFKB1,FGFR1OP,ABCB9,GDNFA,RASGRP1 |
| magnesium ion binding | TSSK1,TSSK2,WEE2,NUDT18,PPM1A,PPA1,SNRK,ERN1,FAN1,EYA2 |
| phosphopyruvate hydratase activity | ENO1A,ENO4,ENO1B,GM5506,ENO1,ENO3 |
| protein heterodimerization activity | TRP53,Defa-rs7,H3F3C,BCL2,H2AFZ,HIST1H4L,HER11,FLOT1,ROPN1B,HIST1H2BK |
Interacting Protein
ENO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENO2.
Ywhae;Ywhaz;Kcnma1
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References
- Fernandez-Garcia, A; Alvarez-Garcia, G; et al. Identification of Besnoitia besnoiti proteins that showed differences in abundance between tachyzoite and bradyzoite stages by difference gel electrophoresis. PARASITOLOGY 140:999-1008(2013).
- Nakamura, N; Dai, QS; et al. Disruption of a Spermatogenic Cell-Specific Mouse Enolase 4 (Eno4) Gene Causes Sperm Structural Defects and Male Infertility. BIOLOGY OF REPRODUCTION 88:-(2013).
