EDNRA
-
Official Full Name
endothelin receptor type A -
Overview
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] -
Synonyms
EDNRA;endothelin receptor type A;ETA;ET-A;ETAR;ETRA;ETA-R;hET-AR;endothelin-1 receptor;G protein-coupled receptor;endothelin receptor subtype A;endothelin-1-specific receptor
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Chicken
- Rat
- Bovine
- Mus musculus
- Sus scrofa (Pig)
- Dog
- Sheep
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- Yeast
- GST
- Non
- His
- Avi&Fc&His
Involved Pathway
EDNRA involved in several pathways and played different roles in them. We selected most pathways EDNRA participated on our site, such as Calcium signaling pathway,Class A/1 (Rhodopsin-like receptors),EGFR-dependent Endothelin signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endothelins | COL3A1,CYSLTR1,EDN3,COL1A2,EDN1,EDN2,EDNRB |
| G alpha (q) signalling events | ADRA1D,OPN4.1,ANXA1,AGTR1,HCRT,PMCH,EDN3,FPR-RS6,LPAR1,ARHGEF25 |
| EGFR-dependent Endothelin signaling events | EDN1 |
| Class A/1 (Rhodopsin-like receptors) | CCK,SSTR4,CCL19A.2,ADORA1,TRH,PNOC,OPN4,OXGR1A.3,RXFP2,RLN3 |
| GPCR ligand binding | LPAR2A,RLN2,CCL35.1,TAC2,ADM2,RHOL,DRD5,CCR7,NMUR1,GRP |
| Endothelin | ECE1,CNN1,EDN1,EDNRB,MYL1,CALCA,RAMP1,CALCRL |
| Calcium signaling pathway | LTB4R2,TACR3A,SLC25A31,HTR7,PLCD1A,ADORA2AA,GNA11,ADORA2B,SLC25A6,GRIN1B |
| GPCR downstream signaling | PYY,ABR,AMCF-II,SSTR5,RLN3A,ADCYAP1R1,OR7D2,OR52J3,TRIO,CASR |
Protein Function
EDNRA has several biochemical functions, for example, endothelin receptor activity,phosphatidylinositol phospholipase C activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRA itself. We selected most functions EDNRA had, and list some proteins which have the same functions with EDNRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endothelin receptor activity | EDNRBA,EDNRAB,EDNRB,EDNRAA |
| phosphatidylinositol phospholipase C activity | CASR,PLCB2,PLCG1,PLCD4,PLCD1B,C3AR1,PLCB4,PLCD1A,CCKBR,CCL5 |
| protein binding | SLC1A1,CD2BP2,PIP5K1C,ALOX5AP,AP1G1,UFD1L,EDDM3B,AFG3L2,FAM65B,MCM6 |
Interacting Protein
EDNRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRA.
EDN1
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