EDN1
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Official Full Name
endothelin 1 -
Overview
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
EDN1;endothelin 1;ET1;PPET1;HDLCQ7;endothelin-1;OTTHUMP00000016038;preproendothelin-1
Recombinant Proteins
- Human
- Rat
- Pig
- Mouse
- Zebrafish
- Guinea pig
- Rabbit
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Yeast
- Synthetic
- In Vitro Cell Free System
- His
- DDK&Myc
- GST
- Non
- Fc
- Fc&Myc
- Avi&Fc&His
- His&KSI
- Flag
Involved Pathway
EDN1 involved in several pathways and played different roles in them. We selected most pathways EDN1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),EGFR-dependent Endothelin signaling events,Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endothelin | CALCA,RAMP1,MYL1,CNN1,EDNRB,EDNRA,ECE1,CALCRL |
| Class A/1 (Rhodopsin-like receptors) | OPN4,PPY,DRD2,OPN1LW2,NMS,CCL35.2,OPN1LW1,HEBP1,LPAR5A,AGTR1 |
| Endothelins | EDNRB,COL3A1,CYSLTR1,EDNRA,COL1A2,EDN2,EDN3 |
| EGFR-dependent Endothelin signaling events | EDNRA |
| GPCR ligand binding | INSL5,KISS1,LTB4R,ADCYAP1B,HRH3,GPR31,RCA2.1,PTH2,PRLH,OPN1LW2 |
| Gastrin-CREB signalling pathway via PKC and MAPK | LTB4R,ANXA1,TAC1,QRFP,KISS1,GPR68,HCRT,FPR-RS6,ANXA1C,OPN4B |
| GPCR downstream signaling | TAE1,AGT,QRFPR,CGA,PMCH,OPN5,RGR,PRKCHB,CXCL11.8,GPR55 |
| G alpha (q) signalling events | KISS1,NPFFR2,ANXA1,QRFP,TRPC6A,APPA,FPR-RS4,CCK,LPAR1,ABHD12 |
Protein Function
EDN1 has several biochemical functions, for example, cytokine activity,endothelin A receptor binding,endothelin B receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDN1 itself. We selected most functions EDN1 had, and list some proteins which have the same functions with EDN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IFNL3,IFNT2,OSM,IL19,IFNPHI4,INHBA,GDF10,CCL20B,WNT1,CMTM7 |
| protein binding | RASSF4,FAM131B,KCNS2,CASP2,SDHB,KIF3B,EIF4G2,FAM49B,SMU1,BMPR1A |
| endothelin B receptor binding | EDN2,EDN3 |
| hormone activity | CCK,GCG,PRL3B1,FSHB,URP2,UCN3,GH1,INS,IGF3,INSL5 |
Interacting Protein
EDN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDN1.
EDNRB;EDNRA;BAG6;COPS6;UBQLN4
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References
- Jacobs, ME; Jeffers, LA; et al. microRNA regulation of endothelin-1 mRNA in renal collecting duct cells. LIFE SCIENCES 118:195-199(2014).
- Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
