ECE1
-
Official Full Name
endothelin converting enzyme 1 -
Overview
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009] -
Synonyms
ECE1;endothelin converting enzyme 1;ECE;endothelin-converting enzyme 1;ECE-1
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Chicken
- Bovine
- Guinea pig
- HEK293
- E.coli
- CHO
- Wheat Germ
- Mammalian Cells
- Human Cells
- In Vitro Cell Free System
- His
- His&T7
- GST
- Non
- Myc&DDK
Involved Pathway
ECE1 involved in several pathways and played different roles in them. We selected most pathways ECE1 participated on our site, such as Corticotropin-releasing hormone,Endothelin,SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | TPPP,IL1RN,CREM,SNTA1,KCNH2,POU2F2,MECP2,MBD1,TSPYL1,SST |
| Endothelin | EDNRA,CNN1,EDN1,CALCA,EDNRB,RAMP1,MYL1,CALCRL |
| Corticotropin-releasing hormone | CRHR1,CYP11A1,CRHR2,IVL,PARP1,CRHBP,JUND,KRT1,ADRBK2,KRT14 |
Protein Function
ECE1 has several biochemical functions, for example, endopeptidase activity,metal ion binding,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECE1 itself. We selected most functions ECE1 had, and list some proteins which have the same functions with ECE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPEP1,RTF1,RSRC2,C9orf86,HIST1H1A,ZFYVE21,PIAS1,KIF20A,TP63,SWSAP1 |
| endopeptidase activity | ADAMTS3,MMP1,PSMB11,PSMA6A,PCSK6,PSMA7,KLK1B5,PSMB10,SENP3,TMEM59 |
| metalloendopeptidase activity | GM12824,ADAMTS10,MMP3,PITRM1,ADAM7,MEP1A.2,BMP1A,TLL2,ADAM28,NLN |
| peptide hormone binding | HCRTR2,AGTR2,ACVR1,NPR1,PTH1RB,NPR3,OXTR,NPR2,GHSR,INHBA |
| protein homodimerization activity | GPD1,RIPK2,TKT,STK10,CRYBB2,ADD1,DST,ATPIF1,MIXL1,LILRB1 |
| metal ion binding | TRIM55B,IKZF5,CLCA5,ESR2B,ZNF771,SP2,MARCH4,FHL3B,NRXN3B,ZNF292B |
Interacting Protein
ECE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECE1.
CLK2;KRTAP10-5;yhjW;dmsB;cona_canen
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