DUSP14
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Official Full Name
dual specificity phosphatase 14 -
Overview
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14;contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP;(mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009;(PubMed 19228121)). -
Synonyms
DUSP14;dual specificity phosphatase 14;dual specificity protein phosphatase 14;MKP 1 like protein tyrosine phosphatase;MKP L;MKP6;MKP-6;MAP kinase phosphatase 6;MKP-1 like protein tyrosine phosphatase;MKP-1-like protein tyrosine phosphatase;mito
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- His&MBP
- T7
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP14-1349R | Recombinant Rhesus monkey DUSP14 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| DUSP14-1570Z | Recombinant Zebrafish DUSP14 | Mammalian Cell | Zebrafish | His |
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| DUSP14-2511H | Recombinant Human DUSP14, His & MBP tagged | E.coli | Human | His&MBP | Met 1 –His 191 |
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| DUSP14-28072TH | Recombinant Human DUSP14, T7 -tagged | E.coli | Human | T7 | Full L. |
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| DUSP14-2928H | Recombinant Human DUSP14 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DUSP14-853H | Recombinant Human DUSP14, T7-tagged | E.coli | Human | T7 | 1-198 a.a. |
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| DUSP14-6781HCL | Recombinant Human DUSP14 293 Cell Lysate | HEK293 | Human | Non |
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| DUSP14-1174R | Recombinant Rhesus Macaque DUSP14 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DUSP14-1174R-B | Recombinant Rhesus Macaque DUSP14 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Dusp14-2683M | Recombinant Mouse Dusp14 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DUSP14-2830H | Recombinant Human DUSP14 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-198aa |
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| DUSP14-4097HF | Recombinant Full Length Human DUSP14 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 198 amino acids |
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| DUSP14-4928H | Recombinant Human DUSP14 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
DUSP14 involved in several pathways and played different roles in them. We selected most pathways DUSP14 participated on our site, such as Hypertrophy Model, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophy Model | JUND,MSTNB,IFRD1,ADAM10A,MSTN,HBEGFB,CYR61,WDR1,ZEB1B,ANKRD1 |
Protein Function
DUSP14 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP14 itself. We selected most functions DUSP14 had, and list some proteins which have the same functions with DUSP14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | PTPN3,DUSP9,PTPN20,PTPRC,MTMR7B,PTENB,MTMR7,DUSP26,CDC25D,PTPN9 |
| protein binding | TRIP10,MEN1,TLX2,SULT1A3,BIRC3,TBX5A,SPTSSA,PAG1,KLF5,MMP14 |
| MAP kinase tyrosine/serine/threonine phosphatase activity | DUSP5,DUSP7,DUSP10,PTPRQ,DUSP1,DUSP4,NT5DC3,DUSP18,SACM1L,DUSP21 |
| poly(A) RNA binding | TIA1,AGO2,SLC3A2,MRPS21,PPIA,EIF3E,SNRPA,DDX6,RBM5,CCT3 |
| protein tyrosine/serine/threonine phosphatase activity | SSH1,DUSP2,SSH2,TPTE,DUSP23A,DUSP22A,PTENA,PTP4A3,PTP4A1,RNGTT |
Interacting Protein
DUSP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP14.
SPERT;ISYNA1
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