TNFRSF21
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Official Full Name
tumor necrosis factor receptor superfamily, member 21 -
Overview
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013] -
Synonyms
TNFRSF21;tumor necrosis factor receptor superfamily, member 21;DR6;CD358;BM-018;tumor necrosis factor receptor superfamily member 21;death receptor 6;TNFR-related death receptor 6
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Zebrafish
- Rat
- HEK293
- E.coli
- Insect Cells
- Sf21 Cells
- Human Cells
- Mammalian Cells
- C-His
- Rabbit
- His
- Non
- Fc
- Avi
- SUMO
Involved Pathway
TNFRSF21 involved in several pathways and played different roles in them. We selected most pathways TNFRSF21 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | LTB,INHBB,FASLG,PRLRA,CCL26,PDGFB,IL2RG,TNFRSF12A,KDR,IFNGR2 |
Protein Function
TNFRSF21 has several biochemical functions, for example, protein binding,tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF21 itself. We selected most functions TNFRSF21 had, and list some proteins which have the same functions with TNFRSF21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RILP,ADI1,TAX1BP1,NAALADL2,EIF2S3,ARL2,SEPT12,KLRB1B,KRTAP10-4,HDAC6 |
| tumor necrosis factor-activated receptor activity | NGFR,FAS,Tnfrsf26,TNFRSF1A,TNFRSF19,TNFRSF11B,TNFRSF9,TNFRSF10B,TNFRSF1B,EDA2R |
Interacting Protein
TNFRSF21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF21 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF21.
APP;TRADD;STX11;MATR3;WASH2P;polg_hcvjf_rna
TNFRSF21 Related Signal Pathway
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