DAG1
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Official Full Name
dystroglycan 1 (dystrophin-associated glycoprotein 1) -
Overview
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010] -
Synonyms
DAG1;dystroglycan 1 (dystrophin-associated glycoprotein 1);A3a;DAG;AGRNR;156DAG;MDDGC7;MDDGC9;dystroglycan
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Rabbit
- Mouse
- Bovine
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Insect Cell
- Yeast
- E.coli expression system
- His
- GST
- Non
- Fc
- His&Myc
- His&Fc&Avi
Involved Pathway
DAG1 involved in several pathways and played different roles in them. We selected most pathways DAG1 participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | CACNG7,PRKAB2,CACNG1,CACNA2D4,MYL2,ITGB4,CACNA2D2,DMD,TGFB1,ITGA3 |
| Integrated Breast Cancer Pathway | USP15,NOXA1,BACH1,USP38,PLK3,SELK,ALKBH1,GDI1,ANXA1,GRN |
| ECM proteoglycans | MATN4,MUSK,FMOD,ITGB3A,HAPLN1,MATN3,VCANB,ASPN,COL9A1,PTPRS |
| ECM-receptor interaction | COL5A1,LAMA1,COL3A1,IBSP,Itga10&Itgb1,THBS3,TNR,LAMB1,COL6A3,COL6A6 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSG2,ACTN1,LEF1,DSC2,DES,CACNB2,LAMA2,SGCG,SGCA,GJA1 |
| Dilated cardiomyopathy | PRKACB,ITGA8,CACNA2D2,TPM1,CACNG8,ADRB1,TGFB2,SGCG,CACNB1,ITGB4 |
| Arrhythmogenic right ventricular cardiomyopathy | DSG2,CACNG2,DES,CDH2,DMD,CACNG3,CTNNA1,DSP,JUP,CTNNA2 |
| Extracellular matrix organization | COL9A1A,MFAP1B,BGNB,FBN1,MMP17,COL6A2,SPARC,PCOLCEB,ADAMTS18,COL28A1A |
Protein Function
DAG1 has several biochemical functions, for example, SH2 domain binding,actin binding,alpha-actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAG1 itself. We selected most functions DAG1 had, and list some proteins which have the same functions with DAG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| laminin-1 binding | SLIT2,LACRT,UBE4A,Shh,NID1,NTN4 |
| dystroglycan binding | CLASP1,AGRN,VCL,AGR2,GYLTL1B,DMD,AGR3,MAP2 |
| SH2 domain binding | SKAP1,MS4A2,SIT1,KHDRBS2,LILRB1,LAX1,SQSTM1,CTR9,NUP62,NLK |
| virus receptor activity | MOG,HSPA1B,CD86,ITGB6,EFNB2,ITGB5,SERPINB3,DPP4,TNFRSF4,EFNB3 |
| calcium ion binding | PCDH1G22,ICN2,EHD2,ABP1,NCL,CAPN1B,MCFD2,CAPNS1A,ASPN,SLC25A23 |
| tubulin binding | AGTPBP1,ALDOA,LRRK2,STMN3,MTAP7D3,RABGAP1,AGBL4,STMN2B,TPPP3,TBCA |
| actin binding | VPS16,MICAL1,MSRB1,MYHZ1.2,TMOD2,MYH10,GC,C19orf21,CNN2,MYH9 |
| alpha-actinin binding | MAGI1,KCNN2,PKD2L1,LRRC10,PPARG,MYOT,KCNA5,RARA,XIRP2,ADORA2A |
| structural constituent of muscle | MYL6B,TPM4,MYL2,ASPH,MYOT,DMD,MYL6,MYL1,CSRP3,MYBPC2 |
Interacting Protein
DAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAG1.
UTRN;DMD;Grb2;ganglioside_gm1;FYN;GPC;DMD;SRC;NCK1;PIK3R1;GRB2;Ank3;rpoB
DAG1 Related Signal Pathway
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