CYP2C19

  • Official Full Name

    cytochrome P450, family 2, subfamily C, polypeptide 19

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

  • Synonyms

    CYP2C19;cytochrome P450, family 2, subfamily C, polypeptide 19;CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19;cytochrome P450 2C19;CPCJ;P450IIC19;CYPIIC17;CYPIIC19;cytochrome P450-11A;cytochrome P450-254C;cyto

Recombinant Proteins

  • Human
  • Cynomolgus
  • E.coli
  • S.Cerevisiae
  • P.pastoris
  • Insect Cells
  • HEK293
  • Protein Conjugation
  • Mammalian Cells
  • Non
  • DDK
  • Myc
  • His
  • Flag

    Involved Pathway

    CYP2C19 involved in several pathways and played different roles in them. We selected most pathways CYP2C19 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP2K19,SULT1C4,CYP4T8,SLC35B3,AADAC,CYP2B6,UGT1B4,CYP3C4,POMCB,GSTO2
    Cytochrome P450 - arranged by substrate type CYP11B2,CYP2C9,CYP19A1,CYP27B1,CYP1B1,CYP2AD3,CYP2A7,CYP46A1,CYP2K16,CYP11A1
    Metabolic pathways TDO2B,MAT1A,ACOT1,PIP5K1A,GSTZ1,NDUFA2,SDHB,SGMS1,Atp5g2,PRPS1L1
    CYP2E1 reactions CYP2B6,CYP2E1,CYP2A13,CYP2A6,CYP2C8,CYP2C9,CYP2F1,CYP2D6,CYP2A7,CYP2Y3
    Chemical carcinogenesis ARNT,GSTO2,UGT1A9,GSTM3,ALDH3B1,UGT2B7,ALDH1A3,GSTA4,ADH1A,UGT1A7
    Arachidonic acid metabolism HPGDS,PTGIS,PLA2G3,GGT5,PLA2G10,CYP2AD3,GPX1,CYP2C37,GPX8,CYP4A11
    Drug metabolism - cytochrome P450 CYP2D6,CYP2E1,CYP2C9,ADH4,CYP2C8,ADH2-2,ADH6,CYP3A5,ADH1C,CYP2A6
    Linoleic acid metabolism CYP2C54,PLA2G4C,CYP2C50,CYP2P6,PLA2G2E,PLA2G4AA,CYP3A25,PLA2G4A,CYP2C9,CYP2P8

    Protein Function

    CYP2C19 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity,(S)-limonene 6-monooxygenase activity,(S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C19 itself. We selected most functions CYP2C19 had, and list some proteins which have the same functions with CYP2C19. You can find most of the proteins on our site.

    Function Related Protein
    heme binding SDHD,CYP4F22,CYP2B19,HBBE2,CYP7A1A,CYP20A1,CYP2C70,CYP2S1,CYP26B1,PXDN
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2AA7,CYP2AA3,CYP2P6,CYP2S1,CYP2AD6,CYP2W1,CYP2C70,CYP2X10.2,CYP2X7,CYP2C18
    arachidonic acid epoxygenase activity CYP2C50,CYP2C55,CYP2C54,CYP2P9,CYP2J5,CYP2P6,CYP2B6,CYP2V1,CYP2Y3,CYP2AA1
    enzyme binding PLCE1,CALU,CDK19,NOXO1,YES1,HSPA2,MLEC,SPDL1,TTN,RAD9
    steroid hydroxylase activity CYP2AA4,CYP2C18,CYP2P6,CYP2V1,CYP2E1,CYP2A7,CYP46A1.2,CYP2D9,CYP2AD6,CYP2AA8
    oxygen binding CYP2E1,MB,CYP2B19,CYP4B1,CYP2V1,CYP2C50,CYP2R1,HBAA,CYP2X10.2,CYP2P6
    (R)-limonene 6-monooxygenase activity CYP2C8,CYP2C9
    (S)-limonene 7-monooxygenase activity CYP2C9,CYP2C8
    monooxygenase activity CYP7A1A,CYP2C70,CYP1A,CYP2Y3,CYP2N13,YWHAQB,CYP8B1,CYP2AA2,CYP2C38,CYP1B1

    Interacting Protein

    CYP2C19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C19.

    Resources

    References

    • Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
    • Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).

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