CXCR2
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Official Full Name
chemokine (C-X-C motif) receptor 2 -
Overview
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
CXCR2;chemokine (C-X-C motif) receptor 2;CD182;IL8R2;IL8RA;IL8RB;CMKAR2;CDw128b;C-X-C chemokine receptor type 2;CXC-R2;CXCR-2;IL-8R B;GRO/MGSA receptor;IL-8 receptor type 2;interleukin 8 receptor B;chemokine (CXC) receptor 2;interleukin 8 receptor, beta;interleukin 8 receptor type 2;interleukin-8 receptor type B;CXCR2 gene for IL8 receptor type B;high affinity interleukin-8 receptor B
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Bovine
- Macaca mulatta
- Dog
- Pan troglodytes
- Gorilla gorilla gorilla (Western lowland gorilla)
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- HEK293
- Mammalian Cells
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- Human Cells
- Non
- His
- DDK&Myc
- GST&His
- GST
- Flag&His
- Avi&Fc&His
- Flag
- His&SUMO
Involved Pathway
CXCR2 involved in several pathways and played different roles in them. We selected most pathways CXCR2 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | AMHR2,PRP2,LTA,IFNPHI1,IFNA13,BMPR1BA,IL20,Ccl9,INHBC,Il23a; Il12b |
| Chemokine signaling pathway | CXCR4,GRK1,CCL21B,MAPK1,PLCB1,CXCL6,CCR8,JAK3,CCR1,GRK7 |
| Phospholipase D signaling pathway | GNA12,PLCB1,PDGFRA,MAPK3,RHEB,LPAR5,PLA2G4F,ARF6,RRAS2,DNM3 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1C2,JAM3,CXCL1,RAC1,MAPK10,ATP6V1B2,GIT1,LYN,MAPK11,ATP6V1E1 |
| Endocytosis | ACAP3,PSD,SH3GLB1A,TFRC,VPS37A,RAB11AL,WASH1,RAB7A,RAB11FIP1,IGF2R |
Protein Function
CXCR2 has several biochemical functions, for example, C-X-C chemokine receptor activity,interleukin-8 binding,interleukin-8 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR2 itself. We selected most functions CXCR2 had, and list some proteins which have the same functions with CXCR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-8 binding | CXCR1,A2M |
| interleukin-8 receptor activity | CXCR1 |
| signal transducer activity | RASGRP3,GNA12,RGS9A,GPR34A,TAS2R103,VMN1R46,OPN4XB,HCAR1-2,PTGER4C,SLC20A1 |
| C-X-C chemokine receptor activity | CXCR6,CXCR7,CXCR4,CXCR4A,CXCR3.1,CCBP2,CXCR4B,CCR9A,CXCR3,CXCR5 |
| protein binding | UBR1,BIK,CLTC,DKK1,KCNG3,LPL,COG5,IKBKB,WNT2,ZFYVE9 |
Interacting Protein
CXCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR2.
CXCL8;GRIA1;fldA;ytpB;argH1;q81ye8_bacan
Resources
Gene Families
What is GPCRWhat is the interleukin (IL) factors and IL gene family
What Is Chemokine
Cytokines
Research Area
Cancer Drug TargetsNeuroinflammation
Natural Killer (NK) Cell CD Antigen
Chemokine Receptors
Neutrophils
T Cell Migration
CD Antigen (Basophils)
CD Antigen (Neutrophils)
CD Antigen (T Cell Migration/Adhesion)
Other T Cell CD Antigen
Megakaryocytes
Asthma Therapeutic Targets
Reperfusion Injury Therapeutic Targets
CXC Chemokine Receptors
Related Services
Related Products
References
- Xia, JL; Xu, XJ; et al. The potential of CXCL5 as a target for liver cancer - what do we know so far?. EXPERT OPINION ON THERAPEUTIC TARGETS 19:141-146(2015).
- Anzai, A; Shimoda, M; et al. Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture. CIRCULATION RESEARCH 116:612-U138(2015).
