CUL2
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Official Full Name
cullin 2 -
Overview
Cullin 2 is a member of the family of human Cullin genes (CUL1, 2, 3, 4a, 4b and 5) homologous to the S. cerevisiae cdc53 gene. It is a component of E3 ubiquitin ligase complexes, including the inactive transcriptional elongation complex SIII, which mediates the ubiquitination of hypoxia-inducible factor (HIF). SIII is formed by three subunits: Elongin C, Elongin B and VHL. Cullin 2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. -
Synonyms
CUL2;cullin 2;MGC131970;cullin-2;CUL-2;OTTHUMP00000019436;OTTHUMP00000019437;OTTHUMP00000019439;OTTHUMP00000019440;OTTHUMP00000019441
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Insect Cells
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Non
- His
- His&GST
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
CUL2 involved in several pathways and played different roles in them. We selected most pathways CUL2 participated on our site, such as HIF- signaling pathway,Ubiquitin mediated proteolysis,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2L3B,FBXW11,UBE2E2,UBE2D3,CBLC,UBE2NA,CUL5,UBE2L3,UBE2IA,SMURF2 |
| HIF- signaling pathway | VEGFA,NOS3,TFRC,PRKCB,INSR,PDHB,PRKCG,MAPK1,NPPA,SLC2A1 |
| Pathways in cancer | FZD5,WNT7A,GNG5,PLCB2,WNT9A,HSP90AB1,STK4,Ar,SMAD2,Fzd4 |
| Renal cell carcinoma | PIK3CD,PAK6,TGFB2,MAPK3,FLCN,EGLN1,KRAS,PIK3R3,VEGFA,PIK3CB |
Protein Function
CUL2 has several biochemical functions, for example, protein binding,contributes_to ubiquitin protein ligase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL2 itself. We selected most functions CUL2 had, and list some proteins which have the same functions with CUL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin protein ligase activity | CUL1A,FBXL14A,FBXL12,FBXL4,CUL5A,SKP2,MED12,CUL5,UBXN6,FBXL22 |
| protein binding | CDKN1A,FAM207A,SEPT3,HSPA1L,MAP3K2,HNRNPU,GGN,BMI1,RPN1,HIST1H2BI |
| ubiquitin protein ligase binding | ARRB1,PRDX6,TRIM28,PRKAR2B,PRKAR1A,MDM2,TMEM189,HSPA8,USP2,MID1 |
Interacting Protein
CUL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL2.
VHL;TCEB1;COMMD1
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