CTNNBIP1
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Official Full Name
catenin, beta interacting protein 1 -
Overview
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
CTNNBIP1;catenin, beta interacting protein 1;beta-catenin-interacting protein 1;beta catenin interacting protein ICAT;ICAT;inhibitor of beta catenin and Tcf 4;MGC15093;inhibitor of beta-catenin and Tcf-4;beta-catenin-interacting protein ICAT
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- GST
- His
- His&T7
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CTNNBIP1 involved in several pathways and played different roles in them. We selected most pathways CTNNBIP1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNBIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | WNT9B,PPP3CB,MAPK10,CCND2A,RAC1A,PRICKLE1,WNT16,DVL1B,SIAH1A,CXXC4 |
Protein Function
CTNNBIP1 has several biochemical functions, for example, armadillo repeat domain binding,beta-catenin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNBIP1 itself. We selected most functions CTNNBIP1 had, and list some proteins which have the same functions with CTNNBIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | APC2,BCL9L,NUMB,CALCOCO1,CD2AP,CDH5,EP300,SALL1,CARM1,GSK3B |
| armadillo repeat domain binding | TCF7L2,AXIN1,CALCOCO1,CNOT1,CHD8,LEF1,AXIN2,STRN,STRN4 |
| protein binding | C15orf57,SF3B4,TAF10,AIM2,ASPA,SLC3A2,DR1,MIEN1,KRT17,DDX39A |
Interacting Protein
CTNNBIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNBIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNBIP1.
CTNNB1;Ctnnb1;JUP
Resources
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References
- Canalis, E; et al. Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches. NATURE REVIEWS ENDOCRINOLOGY 9:575-583(2013).
- Santiago-Gomez, A; Barrasa, JI; et al. 4F2hc-silencing impairs tumorigenicity of HeLa cells via modulation of galectin-3 and beta-catenin signaling, and MMP-2 expression. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833:2045-2056(2013).
